Translocation carcinomas of the kidney Journal Article
| Authors: | Argani, P.; Ladanyi, M. |
| Article Title: | Translocation carcinomas of the kidney |
| Abstract: | A significant proportion of RCCs of children and young adults bear specific chromosome translocations that result in gene fusions that involve members of the MiTF/TFE transcription factor family. These include the Xp11-translocation carcinomas, which bear TFE3 gene fusions, and the renal carcinomas with the t(6;11)(p21;q12), which bear an Alpha-TFEB gene fusion. Both types of translocation result in overexpression of the fusion gene products, such that nuclear labeling for TFE3 or TFEB by immunohistochemistry is a sensitive and specific marker of these respective tumor types. The clinical behavior of these neoplasms relative to conventional, adult-type renal carcinomas remains to be determined, and will be an important area of future investigation. © 2005 Elsevier Inc. All rights reserved. |
| Keywords: | immunohistochemistry; cancer surgery; gene translocation; dna-binding proteins; review; electron microscopy; cell cycle proteins; gene overexpression; carboxy terminal sequence; neoplasm proteins; intron; transcription factor; gene function; genetic transcription; kidney carcinoma; kidney neoplasms; carcinogenesis; transcription factors; cancer genetics; carcinoma, renal cell; kidney surgery; gene fusion; oncogene proteins, fusion; cytoplasm; translocation, genetic; fluorescence analysis; genetic marker; chromosome 12q; chromosome 12p; chromosome xp; basic helix-loop-helix leucine zipper transcription factors; antibody labeling; micromorphology; e1b protein |
| Journal Title: | Clinics in Laboratory Medicine |
| Volume: | 25 |
| Issue: | 2 |
| ISSN: | 0272-2712 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2005-06-01 |
| Start Page: | 363 |
| End Page: | 378 |
| Language: | English |
| DOI: | 10.1016/j.cll.2005.01.008 |
| PUBMED: | 15848741 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 85" - "Export Date: 24 October 2012" - "CODEN: CLMED" - "Source: Scopus" |
