IL-7 and IL-15: Therapeutic cytokines for immunodeficiency Journal Article

  


Authors: Alpdogan, O.; van den Brink, M. R. M.
Article Title: IL-7 and IL-15: Therapeutic cytokines for immunodeficiency
Abstract: Immunodeficiency due to inborn errors, infections, autoimmune diseases and the toxicity of certain therapies, has become an important clinical challenge. Strategies to enhance immune function could improve the outcome for a considerable number of patients. Although myeloid growth factors have found widespread use in clinical medicine, a 'lymphoid growth factor' has not yet been established in clinical use. Several recent studies have proposed two candidate immunostimulatory cytokines: interleukin-7 (IL-7) and IL-15. In this Review, we discuss recent findings regarding the effects of IL-7 and IL-15 on lymphopoiesis and their potential use for the treatment of immunodeficiency.
Keywords: review; nonhuman; human immunodeficiency virus infection; t lymphocyte; t-lymphocytes; animals; cancer immunotherapy; cell maturation; interleukin 7; hematopoietic stem cell transplantation; drug effect; physiology; b lymphocyte; lymphatic system; cytokine; immune response; immunotherapy; drug mechanism; hematopoietic system; natural killer cell; killer cells, natural; acquired immunodeficiency syndrome; monocyte; immune deficiency; macrophage; homeostasis; bone marrow transplantation; primate; lymphopoiesis; t lymphocyte activation; interleukin 15; interleukin-7; interleukin-15; models, immunological; antigenicity
Journal Title: Trends in Immunology
Volume: 26
Issue: 1
ISSN: 1471-4906
Publisher: Elsevier Inc.  
Date Published: 2005-01-01
Start Page: 56
End Page: 64
Language: English
DOI: 10.1016/j.it.2004.11.002
PUBMED: 15629410
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-11144247417&partnerID=40&md5=78d2f0e6c4fa1936aee141c9588affe1
Notes: --- - "Cited By (since 1996): 76" - "Export Date: 24 October 2012" - "CODEN: TIRMA" - "Source: Scopus"
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Seyfettin O Alpdogan
    75 Alpdogan
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