Pregnancy after hematopoietic cell transplantation: A report from the late effects working committee of the Center for International Blood and Marrow Transplant Research (CIBMTR) Journal Article


Authors: Loren, A. W.; Chow, E.; Jacobsohn, D. A.; Gilleece, M.; Halter, J.; Joshi, S.; Wang, Z.; Sobocinski, K. A.; Gupta, V.; Hale, G. A.; Marks, D. I.; Stadtmauer, E. A.; Apperley, J.; Cahn, J. Y.; Schouten, H. C.; Lazarus, H. M.; Savani, B. N.; McCarthy, P. L.; Jakubowski, A. A.; Kamani, N. R.; Hayes-Lattin, B.; Maziarz, R. T.; Warwick, A. B.; Sorror, M. L.; Bolwell, B. J.; Socié, G.; Wingard, J. R.; Rizzo, J. D.; Majhail, N. S.
Article Title: Pregnancy after hematopoietic cell transplantation: A report from the late effects working committee of the Center for International Blood and Marrow Transplant Research (CIBMTR)
Abstract: Preservation of fertility after hematopoietic cell transplantation (HCT) can have a significant influence on the quality of life of transplant survivors. We describe 178 pregnancies in HCT recipients that were reported to the Center for International Blood and Marrow Transplant Research (CIBMTR) between 2002 and 2007. There were 83 pregnancies in female HCT recipients and 95 pregnancies in female partners of male HCT recipients. Indications for transplantation included hematologic and other malignancies (N = 99) and nonmalignant disorders (N = 79, of which 75 patients had severe aplastic anemia). The cohort included recipients of autologous HCT (20 women, 13 men), myeloablative (MA) allogeneic HCT (12 women, 50 men), and nonmyeloablative allogeneic HCT (2 women, 2 men). Age at HCT was <20 years for 50% of women and 19% of men. Conditioning regimens included total body irradiation (TBI) in 16% of women and 19% of men; doses were MA in 10% of women and in 16% of men. Live births were reported in 86% of pregnancies in partners of male transplant patients and 85% of pregnancies in female transplant patients, with most pregnancies occurring 5 to 10 years after HCT. We conclude that some HCT recipients can retain fertility, including patients who have received TBI and/or MA conditioning. Young patients undergoing HCT should be counseled both before and after HCT about potential loss of fertility, methods for preserving fertility, and planning for future pregnancy. Fertility and outcomes of pregnancy after HCT need prospective evaluation in large transplant cohorts. © 2011 American Society for Blood and Marrow Transplantation.
Keywords: adolescent; adult; child; school child; major clinical study; cohort analysis; hematopoietic stem cell transplantation; myeloablative conditioning; nonmyeloablative conditioning; whole body radiation; pregnancy; hematologic disease; female fertility; aplastic anemia; fertility preservation; recipient; allogeneic hematopoietic cell transplantation; autologous hematopoietic cell transplantation; live birth; nonmyeloablative stem cell transplantation
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 17
Issue: 2
ISSN: 1083-8791
Publisher: Elsevier Inc.  
Date Published: 2011-02-01
Start Page: 157
End Page: 166
Language: English
DOI: 10.1016/j.bbmt.2010.07.009
PROVIDER: scopus
PMCID: PMC3017731
PUBMED: 20659574
DOI/URL:
Notes: --- - "Export Date: 4 March 2011" - "CODEN: BBMTF" - "Source: Scopus"
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