High-dose carboplatin-irinotecan-temozolomide: Treatment option for neuroblastoma resistant to topotecan Journal Article
| Authors: | Kushner, B. H.; Kramer, K.; Modak, S.; Cheung, N. K. V. |
| Article Title: | High-dose carboplatin-irinotecan-temozolomide: Treatment option for neuroblastoma resistant to topotecan |
| Abstract: | Background: We report a retrospective study of a novel regimen for neuroblastoma (NB) resistant to standard induction or salvage chemotherapy which now routinely includes topotecan.Patients and Methods: Forty-five patients received carboplatin (500 mg/m2/day, 2×)-irinotecan (50 mg/m2/day, 5×)-temozolomide (250 mg/m2/day, 5×) (HD-CIT). Only one course was planned. Patients with thrombocytopenia indicative of poor bone marrow (BM) reserve resulting from extensive prior therapy received peripheral blood stem cells (PBSCs) post-HD-CIT.Results: Modest acute toxicity allowed outpatient treatment. Low-grade diarrhea was common; there was no mucositis, nephrotoxicity, or cardiotoxicity. Myelosuppression was prolonged but uncomplicated. The absolute neutrophil count reached 500/μl on days 20-30 (median, 25) in 25 patients with satisfactory BM reserve, and on days 9-14 (median, 11) post-PBSC infusion. Anti-NB activity was common against refractory (non-progressing) disease or new relapse occurring off therapy (68% objective response rate), but not against disease progressing on therapy. Seven of 26 patients treated for refractory NB are progression-free and in complete remission following subsequent therapy, including anti-GD2 immunotherapy, at ≥29+ months post-HD-CIT.Conclusions: HD-CIT is appealing as salvage or consolidative therapy because of anti-NB activity and modest non-hematologic toxicity. PBSC support is unnecessary when BM reserve is intact. The wide antineoplastic activity of its three components and their potential for activity against disease in the central nervous system support applicability to other cancers. © 2010 Wiley-Liss, Inc. |
| Keywords: | adolescent; child; clinical article; preschool child; school child; treatment response; cancer recurrence; salvage therapy; cisplatin; doxorubicin; diarrhea; temozolomide; topotecan; cancer staging; drug megadose; carboplatin; progression free survival; multiple cycle treatment; nephrotoxicity; neutrophil count; bone marrow; bone marrow suppression; etoposide; mucosa inflammation; thrombocytopenia; cyclophosphamide; vincristine; retrospective study; irinotecan; immunotherapy; neuroblastoma; cardiotoxicity; erythema; hyperbilirubinemia; peripheral blood stem cell transplantation; thrombocyte transfusion; novel therapeutics |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 56 |
| Issue: | 3 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2011-03-01 |
| Start Page: | 403 |
| End Page: | 408 |
| Language: | English |
| DOI: | 10.1002/pbc.22855 |
| PROVIDER: | scopus |
| PUBMED: | 21049517 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 March 2011" - "CODEN: PBCEA" - "Source: Scopus" |
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