Antibiotics, microbiota, and immune defense Journal Article
| Authors: | Ubeda, C.; Pamer, E. G. |
| Article Title: | Antibiotics, microbiota, and immune defense |
| Abstract: | The gastrointestinal tract microbiota contributes to the development and differentiation of the mammalian immune system. The composition of the microbiota affects immune responses and affects susceptibility to infection by intestinal pathogens and development of allergic and inflammatory bowel diseases. Antibiotic administration, while facilitating clearance of targeted infections, also perturbs commensal microbial communities and decreases host resistance to antibiotic-resistant microbes. Here, we review recent advances that begin to define the interactions between complex intestinal microbial populations and the mammalian immune system and how this relation is perturbed by antibiotic administration. We further discuss how antibiotic-induced disruption of the microbiota and immune homeostasis can lead to disease and we review strategies to restore immune defenses during antibiotic administration. © 2012 Elsevier Ltd. |
| Keywords: | antibiotic agent; review; nonhuman; animals; immune system; infection; allergy; anti-bacterial agents; antibody response; ciprofloxacin; gentamicin; immunity; vancomycin; intestine flora; homeostasis; metronidazole; intestine; cephalosporin; colistin; antibiotics; lymphoid cell; clindamycin; streptomycin; commensal; kanamycin; neomycin; intestinal mucosa; amoxicillin; ampicillin; metagenome; cefalexin; amoxicillin plus clavulanic acid; microbial community; microbiota; immunity, mucosal; quinolone derivative; cefoperazone; inflammasome; feces microflora |
| Journal Title: | Trends in Immunology |
| Volume: | 33 |
| Issue: | 9 |
| ISSN: | 1471-4906 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-09-01 |
| Start Page: | 459 |
| End Page: | 466 |
| Language: | English |
| DOI: | 10.1016/j.it.2012.05.003 |
| PROVIDER: | scopus |
| PMCID: | PMC3427468 |
| PUBMED: | 22677185 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2012" - "CODEN: TIRMA" - "Source: Scopus" |
