IDH1 mutations disrupt blood, brain, and barriers Journal Article

  


Authors: Shih, A. H.; Levine, R. L.
Article Title: IDH1 mutations disrupt blood, brain, and barriers
Abstract: The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic precursors. In the central nervous system, inhibition of collagen and prolyl hydroxylases lead to altered microenvironment and defective angiogenesis. © 2012 Elsevier Inc.
Keywords: signal transduction; vasculotropin; protein expression; acute granulocytic leukemia; mutation; nonhuman; brain tumor; glioma; cancer incidence; cancer grading; colorectal cancer; phenotype; animals; mice; allele; apoptosis; enzyme inhibition; enzyme activity; angiogenesis; neovascularization, pathologic; dna methylation; cell transformation, neoplastic; models, animal; gene expression regulation; brain; epigenetics; cpg island; epigenesis, genetic; glioblastoma; leukemogenesis; blood brain barrier; hematopoietic system; collagen; hematopoietic cell; hematopoietic stem cells; reactive oxygen metabolite; short survey; hematopoiesis; bile duct carcinoma; thyroid cancer; microenvironment; mutant proteins; tumor growth; hypoxia inducible factor 1alpha; nestin; chondrosarcoma; von hippel lindau protein; isocitrate dehydrogenase; citric acid cycle; 2 hydroxyglutaric acid; 2 oxoglutaric acid; isocitrate dehydrogenase 1; histone demethylase; histone methylation; mixed lineage leukemia protein; procollagen proline 2 oxoglutarate 4 dioxygenase; endoplasmic reticulum stress; hypoxia inducible factor 2alpha; gain of function mutation; 5 hydroxymethylcytosine; isocitrate dehydrogenase 2; procollagen lysine 2 oxoglutarate 5 dioxygenase
Journal Title: Cancer Cell
Volume: 22
Issue: 3
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2012-09-11
Start Page: 285
End Page: 287
Language: English
DOI: 10.1016/j.ccr.2012.08.022
PROVIDER: scopus
PUBMED: 22975371
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84866038635&partnerID=40&md5=6e21ad7dab4293e0cb7ab619a154d6ef
Notes: --- - "Export Date: 1 October 2012" - "CODEN: CCAEC" - "Source: Scopus"
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MSK Authors
  1. Alan H Shih
    59 Shih
  2. Ross Levine
    775 Levine
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