Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers Journal Article
| Authors: | Hartz, S. M.; Short, S. E.; Saccone, N. L.; Culverhouse, R.; Chen, L.; Schwantes-An, T. H.; Coon, H.; Han, Y.; Stephens, S. H.; Sun, J.; Chen, X.; Ducci, F.; Dueker, N.; Franceschini, N.; Frank, J.; Geller, F.; Guobjartsson, D.; Hansel, N. N.; Jiang, C.; Keskitalo-Vuokko, K.; Liu, Z.; Lyytikainen, L. P.; Michel, M.; Rawal, R.; Rosenberger, A.; Scheet, P.; Shaffer, J. R.; Teumer, A.; Thompson, J. R.; Vink, J. M.; Vogelzangs, N.; Wenzlaff, A. S.; Wheeler, W.; Xiao, X.; Yang, B. Z.; Aggen, S. H.; Balmforth, A. J.; Baumeister, S. E.; Beaty, T.; Bennett, S.; Bergen, A. W.; Boyd, H. A.; Broms, U.; Campbell, H.; Chatterjee, N.; Chen, J.; Cheng, Y. C.; Cichon, S.; Couper, D.; Cucca, F.; Dick, D. M.; Foroud, T.; Furberg, H.; Giegling, I.; Gu, F.; Hall, A. S.; Hällfors, J.; Han, S.; Hartmann, A. M.; Hayward, C.; Heikkilä, K.; Hewitt, J. K.; Hottenga, J. J.; Jensen, M. K.; Jousilahti, P.; Kaakinen, M.; Kittner, S. J.; Konte, B.; Korhonen, T.; Landi, M. T.; Laatikainen, T.; Leppert, M.; Levy, S. M.; Mathias, R. A.; McNeil, D. W.; Medland, S. E.; Montgomery, G. W.; Muley, T.; Murray, T.; Nauck, M.; North, K.; Pergadia, M.; Polasek, O.; Ramos, E. M.; Ripatti, S.; Risch, A.; Ruczinski, I.; Rudan, I.; Salomaa, V.; Schlessinger, D.; Styrkarsdottir, U.; Terracciano, A.; Uda, M.; Willemsen, G.; Wu, X.; Abecasis, G.; Barnes, K.; Bickeböller, H.; Boerwinkle, E.; Boomsma, D. I. |
| Article Title: | Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers |
| Abstract: | Context: Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968. Objective: To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking. Data Sources: Primary data. Study Selection: Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy. DataExtraction: Uniform statistical analysis scripts were runlocally. Startingwith94 050ever-smokersfrom43studies, we extracted the heavy smokers (CPD>20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33 348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and late-onset smokers (age at onset >16 years), and a logistic regression of heavyvs light smoking with the rs16969968 genotype was computed for each stratum. Meta-analysis was performed within each age-at-onset stratum. Data Synthesis: Individuals with 1 risk allele at rs16969968 who were early-onset smokers were significantly more likely to be heavy smokers in adulthood (odds ratio [OR]=1.45; 95% CI, 1.36-1.55; n=13 843) than were carriers of the risk allele who were late-onset smokers (OR=1.27; 95% CI, 1.21-1.33, n=19 505) (P=.01). Conclusion: These results highlight an increased genetic vulnerability to smoking in early-onset smokers. ©2012 American Medical Association. All rights reserved. |
| Keywords: | unclassified drug; single nucleotide polymorphism; cigarette smoking; allele; protein; cohort analysis; genotype; smoking; gender; onset age; meta analysis; sample size; academic achievement; meta analysis (topic); chrna5 protein; cigarette per day |
| Journal Title: | Archives of General Psychiatry |
| Volume: | 69 |
| Issue: | 8 |
| ISSN: | 0003-990X |
| Publisher: | American Medical Association |
| Date Published: | 2012-08-01 |
| Start Page: | 854 |
| End Page: | 861 |
| Language: | English |
| DOI: | 10.1001/archgenpsychiatry.2012.124 |
| PROVIDER: | scopus |
| PUBMED: | 22868939 |
| PMCID: | PMC3482121 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2012" - "CODEN: ARGPA" - "Source: Scopus" |
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