RAF/MEK dependence of KRAS-mutant pancreatic ductal adenocarcinomas Journal Article

   


Authors: Hanrahan, A. J.; Solit, D. B.
Article Title: RAF/MEK dependence of KRAS-mutant pancreatic ductal adenocarcinomas
Abstract: Studies using genetically engineered mouse models indicate that RAF activation is sufficient to induce pancreatic intraepithelial neoplasms, suggesting that mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK) inhibitor-based combination approaches may have clinical use in patients with pancreatic ductal adenocarcinomas. ©2012 American Association for Cancer Research.
Journal Title: Cancer Discovery
Volume: 2
Issue: 8
ISSN: 2159-8274
Publisher: American Association for Cancer Research  
Date Published: 2012-08-01
Start Page: 666
End Page: 669
Language: English
DOI: 10.1158/2159-8290.cd-12-0308
PROVIDER: scopus
PUBMED: 22886659
PMCID: PMC5031078
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84866245716&partnerID=40&md5=e2a6851d58efa9e080682feaf7c35e11
Notes: --- - "Export Date: 1 October 2012" - "Source: Scopus"
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MSK Authors
  1. David Solit
    779 Solit
  2. Aphrothiti J Hanrahan
    33 Hanrahan
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