Key features of extrauterine pelvic serous tumours (fallopian tube, ovary, and peritoneum) Journal Article
| Authors: | DeLair, D.; Soslow, R. A. |
| Article Title: | Key features of extrauterine pelvic serous tumours (fallopian tube, ovary, and peritoneum) |
| Abstract: | Ovarian serous carcinoma (OSC) is the most common of the ovarian epithelial malignancies, and accounts for most of the mortality. Traditionally, ovarian cancer has been considered to be one disease; however, it is now apparent that it actually consists of many different entities. OSC can be further segregated into two processes: high-grade serous carcinoma (HGSC) and low-grade serous carcinoma. This classification is supported by molecular changes, morphological appearance, clinical behaviour, and distinct precursor lesions. This review will describe in detail these features of OSC, differential diagnosis, prognosis, and recent challenges to the existing hypotheses regarding the origin of these tumours. Special attention will be paid to HGSC and its relationship with BRCA abnormalities, especially those seen in hereditary breast and ovarian cancer syndrome. Finally, treatment options based on specific molecular targets will be discussed. © 2012 Blackwell Publishing Ltd. |
| Keywords: | immunohistochemistry; protein expression; treatment response; cancer surgery; gene mutation; overall survival; genetics; review; cancer risk; cancer staging; follow up; cancer diagnosis; cancer grading; salpingooophorectomy; ovarian cancer; ki 67 antigen; tumor associated leukocyte; cytology; dna repair; progression free survival; antineoplastic metal complex; ovary cancer; peritoneum cancer; breast cancer; differential diagnosis; brca1 protein; brca2 protein; protein p53; dna methylation; ovary; epigenetics; heterozygosity; adjuvant chemotherapy; genetic susceptibility; carcinoma; ovary carcinoma; cytoplasm; cancer relapse; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; familial cancer; down regulation; clear cell carcinoma; ca 125 antigen; taxane derivative; cancer classification; estrogen receptor; k ras protein; b raf kinase; disease specific survival; high grade serous carcinoma; nephroblastoma; uterine tube; peritoneum; transcription factor pax8; ovulation; precursor lesions; high-grade serous carcinoma; low-grade serous carcinoma; cancer prognosis; serous tubal intraepithelial carcinoma; brca1 and 2; serous borderline tumour; low grade serous carcinoma; ovarian serous carcinoma; secretory cell outgrowth |
| Journal Title: | Histopathology |
| Volume: | 61 |
| Issue: | 3 |
| ISSN: | 0309-0167 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2012-09-01 |
| Start Page: | 329 |
| End Page: | 339 |
| Language: | English |
| DOI: | 10.1111/j.1365-2559.2011.04167.x |
| PROVIDER: | scopus |
| PUBMED: | 22372521 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2012" - "CODEN: HISTD" - "Source: Scopus" |
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