CRKL as a lung cancer oncogene and mediator of acquired resistance to EGFR inhibitors: Is it all that it is cracked up to be? Journal Article
| Author: | Ladanyi, M. |
| Article Title: | CRKL as a lung cancer oncogene and mediator of acquired resistance to EGFR inhibitors: Is it all that it is cracked up to be? |
| Abstract: | Cheung and colleagues demonstrate that amplified CRKL can function as a driver oncogene in lung adenocarcinoma, activating both RAS and RAP1 to induce mitogen-activated protein kinase signaling. In addition, they show that CRKL amplification may be another mechanism for primary or acquired resistance to epidermal growth factor receptor kinase inhibitors. © 2011 American Association for Cancer Research. |
| Journal Title: | Cancer Discovery |
| Volume: | 1 |
| Issue: | 7 |
| ISSN: | 2159-8274 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2011-12-01 |
| Start Page: | 560 |
| End Page: | 561 |
| Language: | English |
| DOI: | 10.1158/2159-8290.cd-11-0295 |
| PROVIDER: | scopus |
| PMCID: | PMC3247017 |
| PUBMED: | 22211192 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2012" - "Source: Scopus" |
