Epithelioid pituicytoma Journal Article
| Authors: | Ellis, J. A.; Tsankova, N. M.; D'Amico, R.; Ausiello, J. C.; Canoll, P.; Rosenblum, M. K.; Bruce, J. N. |
| Article Title: | Epithelioid pituicytoma |
| Abstract: | Background: Pituicytomas are rare tumors of the sellar region that are derived from specialized glial cells called pituicytes. They characteristically exhibit spindle-cell features and fascicular or storiform patterns of growth. No other histological variants of this tumor have been described. Case Description: Here we report a diagnostically challenging case of pituicytoma in a 42-year-old man with a sellar mass arising from the pituitary stalk. On histological examination, the tumor displayed an epithelioid histoarchitecture with no characteristic spindle-cell or fascicular growth features. Strong immunopositivity for the pituicyte marker thyroid transcription factor-1 within tumor cells proved essential for diagnosing this unusual pituicytoma variant. Conclusion: Pituicytomas may display epithelioid rather than fascicular or storiform histoarchitecture. Epithelioid pituicytoma variants may be diagnosed in cases such as ours in which both the clinical findings and immunohistochemical analysis suggest a tumor derived from pituicytes. © 2012 Elsevier Inc. |
| Keywords: | adult; case report; brain tumor; follow up; follow-up studies; magnetic resonance imaging; diagnosis, differential; tumor markers, biological; histology; neuroendocrine tumor; tumor cell; spindle cell; craniotomy; epithelioid cells; rare disease; thyroid transcription factor 1; hypophysis; pituitary gland; low-grade glioma; desmopressin; diabetes insipidus; sella turcica tumor; pituitary neoplasms; neurohypophysis; pituicytoma; thyroid transcription factor-1 (ttf-1); epithelioid pituicytoma |
| Journal Title: | World Neurosurgery |
| Volume: | 78 |
| Issue: | 1-2 |
| ISSN: | 1878-8750 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-08-01 |
| Start Page: | 191.E1 |
| End Page: | 191.E7 |
| Language: | English |
| DOI: | 10.1016/j.wneu.2011.09.011 |
| PROVIDER: | scopus |
| PUBMED: | 22120271 |
| PMCID: | PMC3926508 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 September 2012" - "Source: Scopus" |
