Cutting edge: CTLA-4 on effector T cells inhibits in trans Journal Article
| Authors: | Corse, E.; Allison, J. P. |
| Article Title: | Cutting edge: CTLA-4 on effector T cells inhibits in trans |
| Abstract: | CTLA-4 is thought to inhibit effector T cells both intrinsically, by competing with CD28 for B7 ligands, and extrinsically, through the action of regulatory T cells (Tregs). We studied in vivo responses of normal and CTLA-4-deficient Ag-specific murine effector CD4 + T cells. We directly demonstrate that effector T cellrestricted CTLA-4 inhibits T cell responses in a cellextrinsic manner. Cotransfer experiments show that CTLA-4 on normal effector CD4 + T cells completely abrogates the dramatically increased expansion normally experienced by their CTLA-4-deficient counterparts. Neither the wild-type nor the CTLA-4-deficient T cells express the Treg transcription factor Foxp3 when transferred alone or together. Thus, cell-extrinsic inhibition of T cell responses by CTLA-4 is not limited to Tregs but is also a function of effector T cells. Copyright © 2012 by The American Association of Immunologists, Inc. |
| Keywords: | protein expression; nonhuman; transcription factor foxp3; animal cell; mouse; animal experiment; in vivo study; wild type; immunoregulation; cellular immunity; antigen specificity; cd4+ t lymphocyte; effector cell; cytotoxic t lymphocyte antigen 4; cell expansion; lymphocyte function |
| Journal Title: | Journal of Immunology |
| Volume: | 189 |
| Issue: | 3 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2012-08-01 |
| Start Page: | 1123 |
| End Page: | 1127 |
| Language: | English |
| DOI: | 10.4049/jimmunol.1200695 |
| PROVIDER: | scopus |
| PUBMED: | 22753941 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 4 September 2012" - "CODEN: JOIMA" - "Source: Scopus" |
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