Use of recombinant tissue plasminogen activator in cancer patients with acute stroke Journal Article

  


Authors: Graber, J. J.; Nayak, L.; Deangelis, L. M.
Article Title: Use of recombinant tissue plasminogen activator in cancer patients with acute stroke
Abstract: People with cancer may be at increased risk for stroke, especially of cardioembolic and large vessel origin. Some clinicians are reluctant to use recombinant tissue plasminogen activator (rTPA) in the cancer population due to safety concerns. We conducted a retrospective review of patients who received rTPA for acute stroke at an academic cancer center. We report six patients with cancer treated with rTPA at our institution, four of whom had early neurologic recovery. Only one of our six patients suffered minor bleeding as a complication of rTPA. Acute stroke in patients with cancer may be treated with rTPA, and active cancer should not be considered an absolute contraindication to rTPA use.
Keywords: aged; aged, 80 and over; middle aged; retrospective studies; neoplasm; neoplasms; bleeding; retrospective study; stroke; chemically induced disorder; tissue plasminogen activator; fibrinolytic agent; fibrinolytic agents; hemorrhage
Journal Title: Journal of Neuro-Oncology
Volume: 107
Issue: 3
ISSN: 0167-594X
Publisher: Springer  
Date Published: 2012-05-01
Start Page: 571
End Page: 573
Language: English
DOI: 10.1007/s11060-011-0780-5
PUBMED: 22179814
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84864328560&partnerID=40&md5=feccbc05460367d698505e32fbc05c6d
Notes: --- - "Export Date: 24 August 2012" - "Source: Scopus"
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MSK Authors
  1. Lisa De Angelis
    576 De Angelis
  2. Jerome Jeffrey Graber
    24 Graber
  3. Lakshmi Nayak
    18 Nayak
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