Sarcomas with spindle cell morphology Journal Article
| Authors: | Collini, P.; Sorensen, P. H. B.; Patel, S.; Blay, J. Y.; Issels, R. D.; Maki, R. G.; Eriksson, M.; del Muro, X. G. |
| Article Title: | Sarcomas with spindle cell morphology |
| Abstract: | In the days before the term "high-grade undifferentiated pleomorphic sarcoma" came into use, one of the most common sarcoma diagnoses was "malignant fibrous histiocytoma," and before that, in an era before immunohistochemistry, "fibrosarcoma" was used to describe most sarcomas. "Spindle cell" is a descriptive phrase that denotes the cellular shape of many of the sarcomas encountered in the adult population. As a result, they are usually treated differently from small round cell sarcomas, and have different biological characteristics than those tumors and sarcomas with epithelioid morphology. As a very broad generalization, sarcomas with a spindle cell microscopic morphology occur in adults and are treated primarily with surgery and often adjuvant or neoadjuvant radiation as primary therapy. In comparison to small round cell sarcomas such as Ewing sarcoma, the use of adjuvant chemotherapy remains controversial, and the sensitivity of these tumors to chemotherapy in the metastatic setting is highly variable. In this article, we describe some of the clinical and biological characteristics of this group of sarcomas. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | immunohistochemistry; cancer survival; clinical feature; clinical trial; histopathology; sorafenib; bevacizumab; doxorubicin; sunitinib; cancer combination chemotherapy; cancer risk; drug efficacy; liver cell carcinoma; gemcitabine; paclitaxel; cancer adjuvant therapy; cancer radiotherapy; chemotherapy, adjuvant; temozolomide; topotecan; drug megadose; antineoplastic agent; cancer grading; gastrointestinal stromal tumor; imatinib; cell structure; drug inhibition; dacarbazine; metastasis; multiple cycle treatment; etoposide; vincristine; continuous infusion; angiosarcoma; cancer research; kidney carcinoma; ifosfamide; deforolimus; docetaxel; ewing sarcoma; sarcoma; protein kinase inhibitors; fibrosarcoma; sulindac; gene fusion; fusion gene; pazopanib; soft tissue sarcoma; tamoxifen; epirubicin; chromosome translocation; translocation, genetic; spindle cell; anthracycline derivative; camptothecin derivative; dna topoisomerase inhibitor; mesna; trabectedin; dermatofibroma; heat shock response; hemangiopericytoma; hyperthermia; leiomyosarcoma; malignant fibrous histiocytoma; rhabdomyosarcoma; solitary fibrous tumor; spindle cell sarcoma; synovial sarcoma; heat-shock response; hyperthermia, induced; sarcoma, synovial |
| Journal Title: | Seminars in Oncology |
| Volume: | 36 |
| Issue: | 4 |
| ISSN: | 0093-7754 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-08-01 |
| Start Page: | 324 |
| End Page: | 337 |
| Language: | English |
| DOI: | 10.1053/j.seminoncol.2009.06.007 |
| PUBMED: | 19664493 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: SOLGA" - "Source: Scopus" |
