Hereditary and familial kidney cancer Journal Article
| Authors: | Coleman, J. A.; Russo, P. |
| Article Title: | Hereditary and familial kidney cancer |
| Abstract: | PURPOSE OF REVIEW: Changing strategies in the evaluation and treatment of renal neoplasms have been fostered by developments in the understanding of the genetics and molecular biology of renal tumors. Many of these discoveries have come from research into hereditary kidney cancer syndromes and the genetic mutations responsible for tumorigenesis. The purpose of this review is to familiarize the reader with the known heritable forms of kidney cancer, the recent advances in the field and their impact on patient management. RECENT FINDINGS: Genetic and phenotypic characterization of renal cancer syndromes includes von Hippel-Lindau disease, Birt-Hogg-Dube syndrome, hereditary papillary renal carcinoma, and hereditary leiomyomatosis and renal carcinoma. SUMMARY: Hereditary kidney cancer syndromes offer valuable insight into the pathogenesis of kidney cancer through identification of the underlying genetic mechanisms common to hereditary and sporadic forms of disease. An understanding of the manifestations of these diseases is necessary to allow for accurate diagnosis of patients and to provide the opportunity for appropriate screening. Conservative management strategies have been developed and should be followed to limit treatment-related morbidity. © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins. |
| Keywords: | gene mutation; genetics; clinical feature; pathogenesis; review; diagnostic accuracy; phenotype; gene; morbidity; carcinoma, papillary; kidney carcinoma; kidney neoplasms; carcinogenesis; oncogene; patient care; carcinoma, renal cell; familial cancer; birt-hogg-dube; hereditary kidney cancer; hereditary leiomyomatosis renal cell carcinoma; hereditary papillary renal carcinoma; von hippel-lindau; bhd gene; birt hogg dube syndrome; c met gene; genetic risk; kidney cancer; leiomyomatosis; molecular biology; papillary carcinoma; vhl gene; von hippel lindau disease; von hippel-lindau disease |
| Journal Title: | Current Opinion in Urology |
| Volume: | 19 |
| Issue: | 5 |
| ISSN: | 0963-0643 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2009-09-01 |
| Start Page: | 478 |
| End Page: | 485 |
| Language: | English |
| DOI: | 10.1097/MOU.0b013e32832f0d40 |
| PUBMED: | 19584731 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: CUOUE" - "Source: Scopus" |
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