TGF-β control of stem cell differentiation genes Journal Article
| Authors: | Massague, J.; Xi, Q. |
| Article Title: | TGF-β control of stem cell differentiation genes |
| Abstract: | The canonical TGF-β/Smad signaling pathway was delineated in the mid 90s and enriched over the past decade with many findings about its specificity, regulation, networking, and malfunctions in disease. However, a growing understanding of the chromatin status of a critical class of TGF-β target genes - the genes controlling differentiation of embryonic stem cells - recently prompted a reexamination of this pathway and its critical role in the regulation of stem cell differentiation. The new findings reveal master regulators of the pluripotent state set the stage for Smad-mediated activation of master regulators of the next differentiation stage. Furthermore, a novel branch of the TGF-β/Smad pathway has been identified in which a chromatin-reading Smad complex makes the master differentiation genes accessible to canonical Smad complexes for transcriptional activation. These findings provide exciting new insights into the global role of TGF-β signaling in the regulators of stem cell fate. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| Keywords: | signal transduction; unclassified drug; review; nonhuman; binding affinity; protein domain; protein function; gene targeting; smad protein; smad2 protein; smad3 protein; transforming growth factor beta; protein protein interaction; transcription initiation; protein binding; cell fate; cell differentiation; structure activity relation; stem cell; transcription regulation; epigenetics; chromatin; transcription; gene control; structure analysis; rna polymerase ii; cell activity; octamer transcription factor 4; differentiation; regulator protein; chromatin structure; epigenetic; smad4 protein; regulator gene; tgf-β; protein nodal; goosecoid protein; tripartite motif protein 33; transforming growth factor beta gene |
| Journal Title: | FEBS Letters |
| Volume: | 586 |
| Issue: | 14 |
| ISSN: | 0014-5793 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2012-07-04 |
| Start Page: | 1953 |
| End Page: | 1958 |
| Language: | English |
| DOI: | 10.1016/j.febslet.2012.03.023 |
| PROVIDER: | scopus |
| PUBMED: | 22710171 |
| PMCID: | PMC3466472 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2012" - "CODEN: FEBLA" - "Source: Scopus" |
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