Efficacy of hypomethylating agents in therapy-related myelodysplastic syndromes Journal Article
| Authors: | Klimek, V. M.; Dolezal, E. K.; Tees, M. T.; Devlin, S. M.; Stein, K.; Romero, A.; Nimer, S. D. |
| Article Title: | Efficacy of hypomethylating agents in therapy-related myelodysplastic syndromes |
| Abstract: | We retrospectively assessed morphologic and cytogenetic responses to 5-azacytidine and decitabine in a cohort of 42 adult therapy-related myelodysplastic syndromes (tMDS) patients treated at Memorial Sloan-Kettering Cancer Center and in 2 industry-sponsored decitabine trials (D0007 and DACO-020). The overall response rate (complete remission. +. marrow CR. +. hematologic improvement) was 38%, including 6 patients with complete remission (14%), 6 with marrow CR with or without hematologic improvement (14%), and 4 with hematologic improvement alone (10%). We conclude that DNA methyltransferase inhibitors showed activity in tMDS that is roughly comparable to that seen in de novo MDS. © 2012 Elsevier Ltd. |
| Keywords: | adult; cancer chemotherapy; cancer survival; treatment outcome; aged; aged, 80 and over; middle aged; leukemia; retrospective studies; acute granulocytic leukemia; major clinical study; overall survival; allogeneic stem cell transplantation; drug withdrawal; unspecified side effect; cancer radiotherapy; outcome assessment; follow up; multiple cycle treatment; antimetabolites, antineoplastic; retrospective study; dna methylation; myelodysplastic syndrome; drug response; remission; 5 aza 2' deoxycytidine; neoplasms, second primary; drug treatment failure; dna (cytosine-5-)-methyltransferase; azacitidine; induction chemotherapy; myelodysplastic syndromes; 5-azacytidine; decitabine; therapy-related cancer |
| Journal Title: | Leukemia Research |
| Volume: | 36 |
| Issue: | 9 |
| ISSN: | 0145-2126 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2012-09-01 |
| Start Page: | 1093 |
| End Page: | 1097 |
| Language: | English |
| DOI: | 10.1016/j.leukres.2012.04.025 |
| PROVIDER: | scopus |
| PUBMED: | 22608310 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 1 August 2012" - "CODEN: LERED" - "Source: Scopus" |
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