Bevacizumab for the treatment of high-grade glioma Journal Article
| Authors: | Khasraw, M.; Simeonovic, M.; Grommes, C. |
| Article Title: | Bevacizumab for the treatment of high-grade glioma |
| Abstract: | Introduction: Gliomas are highly vascular and rich in vascular endothelial growth factor (VEGF) that promotes angiogenesis. Bevacizumab is a monoclonal antibody against VEGF inhibiting angiogenesis by preventing receptor activation. Phase II clinical trials using bevacizumab in both newly diagnosed and recurrent high-grade glioma (HGG) showed promising results. Areas covered: This is a review of clinical trials investigating bevacizumab in newly diagnosed and recurrent HGGs with a focus on outcome results. A future perspective about the expected role of bevacizumab is given. Bevacizumab efficacy, safety and tolerability, the combination of radiation and bevacizumab as well as the use of bevacizumab to treat pseudoprogression are discussed. Further criteria of response evaluation needed to be adjusted in the age of anti-angiogenic therapy and this will be discussed. Expert opinion: Bevacizumab has been shown to be safe and tolerable in HGG. In the recurrent disease setting, bevacizumab alone might be sufficient for a clinical benefit and is currently approved as a single agent for this indication. While clinical trials demonstrate a prolonged progression-free survival in bevacizumab-treated HGG, a benefit on OS has not been demonstrated yet. Bevacizumab has also been introduced into other settings in neuro-oncology including concurrent administration with re-irradiation for recurrent HGG. © 2012 Informa UK, Ltd. |
| Keywords: | treatment outcome; treatment response; disease-free survival; overall survival; drug tolerability; fatigue; neutropenia; review; bevacizumab; erlotinib; diarrhea; drug efficacy; drug safety; hypertension; hypophosphatemia; cancer radiotherapy; radiotherapy, adjuvant; temozolomide; glioma; brain neoplasms; carboplatin; progression free survival; multiple cycle treatment; neoplasm recurrence, local; etoposide; nausea; thrombocytopenia; vomiting; carmustine; cranial irradiation; time factors; irinotecan; gastrointestinal toxicity; disease progression; thromboembolism; vein thrombosis; tumor recurrence; glioblastoma; weakness; intestine perforation; tumor growth; stereotactic body radiation therapy; angiogenesis inhibitors; brain ischemia; epistaxis; wound dehiscence; brain hemorrhage; proteinuria; tumor bleeding; chemoradiotherapy; posterior reversible encephalopathy syndrome; high-grade glioma; anti-angiogenic therapy; antibodies, monoclonal, humanized; neoplasm grading; convulsion; metronomic drug administration |
| Journal Title: | Expert Opinion on Biological Therapy |
| Volume: | 12 |
| Issue: | 8 |
| ISSN: | 1471-2598 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2012-08-01 |
| Start Page: | 1101 |
| End Page: | 1111 |
| Language: | English |
| DOI: | 10.1517/14712598.2012.694422 |
| PROVIDER: | scopus |
| PUBMED: | 22663137 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2012" - "CODEN: EOBTA" - "Source: Scopus" |
