Ubiquitin removal in the TGF-β pathway Journal Article
| Authors: | Aggarwal, K.; Massague, J. |
| Article Title: | Ubiquitin removal in the TGF-β pathway |
| Abstract: | The transforming growth factor (TGF-β) pathway is regulated by ubiquitin-mediated proteolysis at different levels. Two studies now identify deubiquitinating enzymes (DUBs) for the TGF-β type I receptor. Both ubiquitin-specific peptidase-4 (USP4) and-15 (USP15) extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action. © 2012 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | signal transduction; protein kinase b; protein phosphorylation; unclassified drug; nonhuman; ubiquitin; protein function; complex formation; smad2 protein; transforming growth factor beta; protein degradation; protein depletion; protein protein interaction; enzyme activation; enzyme phosphorylation; transforming growth factor beta receptor; malignant neoplastic disease; short survey; tumor promotion; peptidase; transforming growth factor beta 1 receptor; ubiquitin specific peptidase 15; ubiquitin specific peptidase 4 |
| Journal Title: | Nature Cell Biology |
| Volume: | 14 |
| Issue: | 7 |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2012-06-29 |
| Start Page: | 656 |
| End Page: | 657 |
| Language: | English |
| DOI: | 10.1038/ncb2534 |
| PROVIDER: | scopus |
| PUBMED: | 22743709 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2012" - "CODEN: NCBIF" - "Source: Scopus" |
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