Spontaneous remission in thyroid cancer patients after biochemical incomplete response to initial therapy Journal Article


Authors: Vaisman, F.; Momesso, D.; Bulzico, D. A.; Pessoa, C. H. C. N.; Dias, F.; Corbo, R.; Vaisman, M.; Tuttle, R. M.
Article Title: Spontaneous remission in thyroid cancer patients after biochemical incomplete response to initial therapy
Abstract: Objective: To validate the American Thyroid Association (ATA) initial risk of recurrence scheme and the Memorial Sloan Kettering Cancer Center (MSKCC) response to therapy re-stratification approach in a large cohort of patients with differentiated thyroid cancer (DTC) treated outside of the United States. Design: Retrospective chart review. Patients: Five hundred and six patients with DTC followed for a median of 10 years after total thyroidectomy and RAI remnant ablation at a major cancer centre in Brazil. Measurements: Final clinical outcomes were assessed based on American Joint Cancer Committee (AJCC)/Union Internationale Contre le Cancer (UICC) staging, ATA risk stratification and response to therapy assessment (excellent, acceptable, biochemical incomplete and structural incomplete). Results: The AJCC/UICC staging system did not adequately stratify patients with regard to the risk of recurrence/persistent disease. However, the ATA system demonstrated a 13% risk of recurrent/persistent disease in low-risk patients, 36% in intermediate risk patients, and 68% in high-risk patients. Furthermore, an excellent response to therapy decreased the risk of recurrent/ persistent disease to 1.4%. At the time of final follow-up, 34% of the biochemical incomplete response patients had been reclassified as having no evidence of disease (NED) without having received any additional therapy beyond continue levothyroxine suppression. Conversely, even after additional therapies, only 9% of the patients with an incomplete structural response were eventually re-classified as NED. Conclusions: These data validate the ATA risk classification as an excellent initial predictor of recurrent/persistent disease and confirm the clinical utility of the MSKCC dynamic risk assessment system in a cohort of patients evaluated and treated outside the United States. © 2012 Blackwell Publishing Ltd.
Keywords: adolescent; adult; controlled study; treatment outcome; treatment response; aged; aged, 80 and over; middle aged; retrospective studies; young adult; major clinical study; cancer patient; neoadjuvant therapy; cancer staging; outcome assessment; follow up; neoplasm staging; cohort studies; tumor markers, biological; risk factors; medical record review; high risk patient; risk assessment; cancer regression; societies, medical; carcinoma; recurrent disease; thyroidectomy; thyroid neoplasms; brazil; levothyroxine; stratification; remission, spontaneous; differentiated thyroid cancer
Journal Title: Clinical Endocrinology
Volume: 77
Issue: 1
ISSN: 0300-0664
Publisher: Wiley Blackwell  
Date Published: 2012-07-01
Start Page: 132
End Page: 138
Language: English
DOI: 10.1111/j.1365-2265.2012.04342.x
PROVIDER: scopus
PUBMED: 22248037
DOI/URL:
Notes: --- - "Export Date: 2 July 2012" - "CODEN: CLENA" - "Source: Scopus"
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MSK Authors
  1. Robert M Tuttle
    350 Tuttle