Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC Journal Article
| Authors: | Travis, R. C.; Allen, N. E.; Appleby, P. N.; Price, A.; Kaaks, R.; Chang-Claude, J.; Boeing, H.; Aleksandrova, K.; Tjønneland, A.; Johnsen, N. F.; Overvad, K.; Ramón Quirós, J.; González, C. A.; Molina-Montes, E.; Sánchez, M. J.; Larranaga, N.; Castaño, J. M. H.; Ardanaz, E.; Khaw, K. T.; Wareham, N.; Trichopoulou, A.; Karapetyan, T.; Rafnsson, S. B.; Palli, D.; Krogh, V.; Tumino, R.; Vineis, P.; Bueno-de-Mesquita, H. B.; Stattin, P.; Johansson, M.; Fedirko, V.; Norat, T.; Siddiq, A.; Riboli, E.; Key, T. J. |
| Article Title: | Prediagnostic concentrations of plasma genistein and prostate cancer risk in 1,605 men with prostate cancer and 1,697 matched control participants in EPIC |
| Abstract: | Purpose: Data from prospective epidemiological studies in Asian populations and from experimental studies in animals and cell lines suggest a possible protective association between dietary isoflavones and the development of prostate cancer. We examined the association between circulating concentrations of genistein and prostate cancer risk in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition. Methods: Concentrations of the isoflavone genistein were measured in prediagnostic plasma samples for 1,605 prostate cancer cases and 1,697 matched control participants. Relative risks (RRs) for prostate cancer in relation to plasma concentrations of genistein were estimated by conditional logistic regression. Results: Plasma genistein concentrations were not associated with prostate cancer risk; the multivariate relative risk for men in the highest fifth of genistein compared with men in the lowest fifth was 1.00 (95 % confidence interval: 0.79, 1.27; p linear trend = 0.82). There was no evidence of heterogeneity in this association by age at blood collection, country of recruitment, or cancer stage or histological grade. Conclusion: Plasma genistein concentration was not associated with prostate cancer risk in this large cohort of European men. © 2012 The Author(s). |
| Keywords: | adult; controlled study; aged; middle aged; case control study; case-control studies; histopathology; cancer risk; cancer staging; cancer diagnosis; cancer grading; prospective studies; protein blood level; logistic models; risk factors; risk factor; risk assessment; questionnaires; prostate cancer; europe; prostatic neoplasms; registries; tandem mass spectrometry; multivariate analysis; chromatography, high pressure liquid; plasma; prospective; genistein; isoflavone; phyto-estrogen |
| Journal Title: | Cancer Causes & Control |
| Volume: | 23 |
| Issue: | 7 |
| ISSN: | 0957-5243 |
| Publisher: | Springer |
| Date Published: | 2012-07-01 |
| Start Page: | 1163 |
| End Page: | 1171 |
| Language: | English |
| DOI: | 10.1007/s10552-012-9985-y |
| PROVIDER: | scopus |
| PMCID: | PMC3369135 |
| PUBMED: | 22674291 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 July 2012" - "CODEN: CCCNE" - "Source: Scopus" |
