Changes observed in slow-growing melanomas during long-term dermoscopic monitoring Journal Article

Authors: Terushkin, V.; Dusza, S. W.; Scope, A.; Argenziano, G.; Bahadoran, P.; Cowell, L.; De Giorgi, V.; Ferrara, G.; Kittler, H.; Malvehy, J.; Menzies, S.; Piccolo, D.; Puig, S.; Rubegni, P.; Stanganelli, I.; Thomas, L.; Zalaudek, I.; Marghoob, A. A.
Article Title: Changes observed in slow-growing melanomas during long-term dermoscopic monitoring
Abstract: Background: Melanomas vary in growth rate from rapidly developing nodular melanomas to slow-growing melanomas (SGM) that hardly change over years. Objectives: To evaluate longitudinal changes in dermoscopic findings of SGM. Methods We retrospectively analysed a dermoscopic image dataset from 15 pigmented lesion clinics, of SGM that were followed sequentially by digital dermoscopy for at least 1 year. We evaluated baseline and follow-up images for changes in global pattern, organization, colours, structure and size. Results: Our series consisted of 92 SGM. On follow-up, these melanomas developed the following dermoscopic findings: more homogeneous and less reticular global dermoscopic pattern; more frequent disorganization of pattern (baseline, 67% vs. follow-up, 79%); decreased prominence of light brown colour, increased prominence of dark brown colour, and increased frequency of the colours red, white, grey, blue and black (baseline: 29%, 3%, 18%, 6% and 33% vs. follow-up: 41%, 10%, 31%, 13% and 45%, respectively); decrease in prominence of dermoscopic structure of pigmented network, with a concomitant increase in prominence of structureless areas; and increased prominence or new appearance of melanoma-specific dermoscopic structures, including negative network, blue-white structures and blotches. The majority of lesions (75%) remained the same size or grew by < 2 mm in diameter. An increase in lesion size was associated with change in the total number of colours and structures (χ 2 = 14·3, P = 0·027) at follow-up. Conclusions: While their diameter changed minimally over time, most SGM became more disorganized, revealed loss of network in favour of structureless areas, and developed new colours. © 2012 British Association of Dermatologists.
Keywords: adult; middle aged; retrospective studies; disease course; follow up; cell structure; melanoma; dermoscopy; image analysis; skin neoplasms; epiluminescence microscopy; skin discoloration; tumor growth; growth rate; slow growing melanoma
Journal Title: British Journal of Dermatology
Volume: 166
Issue: 6
ISSN: 0007-0963
Publisher: Blackwell Publishing  
Date Published: 2012-06-01
Start Page: 1213
End Page: 1220
Language: English
DOI: 10.1111/j.1365-2133.2012.10846.x
PROVIDER: scopus
PUBMED: 22283805
Notes: --- - "Export Date: 2 July 2012" - "CODEN: BJDEA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Stephen Dusza
    255 Dusza
  2. Alon Scope
    123 Scope
  3. Ashfaq A Marghoob
    507 Marghoob