Pelvic lymph node dissection for patients with elevated risk of lymph node invasion during radical prostatectomy: Comparison of open, laparoscopic and robot-assisted procedures Journal Article


Authors: Silberstein, J. L.; Vickers, A. J.; Power, N. E.; Parra, R. O.; Coleman, J. A.; Pinochet, R; Touijer, K. A.; Scardino, P. T.; Eastham, J. A.; Laudone, V. P.
Article Title: Pelvic lymph node dissection for patients with elevated risk of lymph node invasion during radical prostatectomy: Comparison of open, laparoscopic and robot-assisted procedures
Abstract: Background and Purpose: Published outcomes of pelvic lymph node dissection (PLND) during robot-assisted laparoscopic prostatectomy (RALP) demonstrate significant variability. The purpose of the study was to compare PLND outcomes in patients at risk for lymph node involvement (LNI) who were undergoing radical prostatectomy (RP) by different surgeons and surgical approaches. Patients and Methods: Institutional policy initiated on January 1, 2010, mandated that all patients undergoing RP receive a standardized PLND with inclusion of the hypogastric region when predicted risk of LNI was ≥2%. We analyzed the outcomes of consecutive patients meeting these criteria from January 1 to September 1, 2010 by surgeons and surgical approach. All patients underwent RP; surgical approach (open radical retropubic [ORP], laparoscopic [LRP], RALP) was selected by the consulting surgeon. Differences in lymph node yield (LNY) between surgeons and surgical approaches were compared using multivariable linear regression with adjustment for clinical stage, biopsy Gleason grade, prostate-specific antigen (PSA) level, and age. Results: Of 330 patients (126 ORP, 78 LRP, 126 RALP), 323 (98%) underwent PLND. There were no significant differences in characteristics between approaches, but the nomogram probability of LNI was slightly greater for ORP than RALP (P=0.04). LNY was high (18 nodes) by all approaches; more nodes were removed by ORP and LRP (median 20, 19, respectively) than RALP (16) after adjusting for stage, grade, PSA level, and age (P=0.015). Rates of LNI were high (14%) with no difference between approaches when adjusted for nomogram probability of LNI (P=0.15). Variation in median LNY among individual surgeons was considerable for all three approaches (11-28) (P=0.005) and was much greater than the variability by approach. Conclusions: PLND, including hypogastric nodal packet, can be performed by any surgical approach, with slightly different yields but similar pathologic outcomes. Individual surgeon commitment to PLND may be more important than approach. © Copyright 2012, Mary Ann Liebert, Inc. 2012.
Keywords: adult; aged; middle aged; major clinical study; outcome assessment; lymph node dissection; pelvis lymph node; lymph nodes; pelvis; laparoscopy; lymph node excision; prostate specific antigen; risk factors; age; gleason score; prostatectomy; surgeon; multiple linear regression analysis; neoplasm invasiveness; robotics; nomogram; lymphadenopathy; hypogastric plexus
Journal Title: Journal of Endourology
Volume: 26
Issue: 6
ISSN: 0892-7790
Publisher: Mary Ann Liebert, Inc  
Date Published: 2012-06-01
Start Page: 748
End Page: 753
Language: English
DOI: 10.1089/end.2011.0266
PROVIDER: scopus
PMCID: PMC3357075
PUBMED: 22050490
DOI/URL:
Notes: --- - "Export Date: 2 July 2012" - "CODEN: JENDE" - "Source: Scopus"
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MSK Authors
  1. Jonathan Coleman
    184 Coleman
  2. Raul O Parra
    9 Parra
  3. Vincent Laudone
    59 Laudone
  4. Peter T Scardino
    621 Scardino
  5. Abdelkrim Karim Touijer
    190 Touijer
  6. Nicholas Edgar Power
    17 Power
  7. Andrew J Vickers
    556 Vickers
  8. James Eastham
    426 Eastham