Initial results with (11)C-acetate positron emission tomography/computed tomography (PET/CT) in the staging of urinary bladder cancer Journal Article
| Authors: | Schoder, H.; Ong, S. C.; Reuter, V. E.; Cai, S.; Burnazi, E.; Dalbagni, G.; Larson, S. M.; Bochner, B. H. |
| Article Title: | Initial results with (11)C-acetate positron emission tomography/computed tomography (PET/CT) in the staging of urinary bladder cancer |
| Abstract: | Purpose: To investigate the utility of 11C-acetate positron emission tomography/computed tomography (PET/CT) for staging of bladder cancer and response assessment after neoadjuvant chemotherapy. Procedures: Seventeen patients underwent 11C-acetate PET/CT ≤1 month before radical cystectomy (RC) and pelvic lymph node dissection (PLND). Ten patients had undergone neoadjuvant chemotherapy prior to PET. Histopathology from RC and PLND (n=16) or nodal biopsy (n=1) served as gold standard. Results: Eight of 10 residual tumors showed abnormal 11C-acetate uptake; two cases of residual TiS were false negative, three cases were false positive, and three true negative. Three patients showed true positive uptake in LN. False positive uptake occurred in 14 LN regions secondary to granulomatous disease after prior intravesical Bacillus Calmette-Guerin (BCG) therapy. Conclusions: 11C-acetate has good sensitivity for bladder cancer and LN metastases. However, false positive uptake due to inflammation or granulomatous infection can occur, limiting the staging utility of 11C-acetate after prior intravesical BCG therapy. © Academy of Molecular Imaging and Society for Molecular Imaging, 2011. |
| Keywords: | adult; clinical article; controlled study; human tissue; aged; middle aged; unclassified drug; histopathology; cancer adjuvant therapy; cancer staging; outcome assessment; lymph node metastasis; staging; cancer diagnosis; lymph nodes; neoplasm staging; disease association; bcg vaccine; controlled clinical trial; image analysis; diagnostic imaging; bladder cancer; urinary bladder neoplasms; drug accumulation; drug uptake; tissue distribution; radioactivity; computer assisted emission tomography; mycobacterium bovis; radiopharmaceutical agent; drug sensitivity; false positive result; image display; pet/ct; granulomatosis; limit of detection; acetates; positron-emission tomography and computed tomography; carbon radioisotopes; carbon acetate c 11; mycobacterium bovis bcg |
| Journal Title: | Molecular Imaging and Biology |
| Volume: | 14 |
| Issue: | 2 |
| ISSN: | 1536-1632 |
| Publisher: | Springer |
| Date Published: | 2012-04-01 |
| Start Page: | 245 |
| End Page: | 251 |
| Language: | English |
| DOI: | 10.1007/s11307-011-0488-0 |
| PROVIDER: | scopus |
| PUBMED: | 21491174 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 July 2012" - "CODEN: CPIMF" - "Source: Scopus" |
