The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement Journal Article
| Authors: | Martins, R. G.; D'Amico, T. A.; Loo, B. W. Jr; Pinder-Schenck, M.; Borghaei, H.; Chaft, J. E.; Ganti, A. K. P.; Kong, F. M.; Kris, M. G.; Lennes, I. T.; Wood, D. E. |
| Article Title: | The management of patients with stage IIIA non-small cell lung cancer with N2 mediastinal node involvement |
| Abstract: | Patients with stage IIIA non-small cell lung cancer, determined based on involvement of ipsilateral mediastinal lymph nodes, represent the most challenging management problem in this disease. Patients with this stage disease may have very different degrees of lymph node involvement. The pathologic confirmation of this involvement is a key step in the therapeutic decision. The difference in the degree of lymph node compromise has prognostic and treatment implications. Based on multiple considerations, patients can be treated with induction chemotherapy, chemoradiotherapy followed by surgery, or definitive chemoradiotherapy without surgery. Data derived from clinical trials have provided incomplete guidance for physicians and their patients. The best therapeutic plan is achieved through the multidisciplinary cooperation of a team specialized in lung cancer. © JNCCN-Journal of the National Comprehensive Cancer Network. |
| Keywords: | cancer chemotherapy; treatment outcome; treatment response; cancer surgery; overall survival; review; cisplatin; doxorubicin; fluorouracil; drug efficacy; drug safety; multimodality cancer therapy; clinical trials as topic; pathophysiology; gemcitabine; cancer patient; nuclear magnetic resonance imaging; positron emission tomography; antineoplastic agent; lymph nodes; lymphatic metastasis; neoplasm staging; diagnostic accuracy; sensitivity and specificity; evidence based medicine; progression free survival; computer assisted tomography; multiple cycle treatment; etoposide; lung non small cell cancer; lung resection; carcinoma, non-small-cell lung; lung neoplasms; morbidity; randomized controlled trials as topic; cyclophosphamide; vincristine; clinical protocol; practice guideline; risk factor; cancer mortality; ifosfamide; vinblastine; docetaxel; cancer invasion; disease severity; computer assisted emission tomography; clinical evaluation; brain metastasis; clinical decision making; lung surgery; mitomycin; mediastinum; thorax surgery; non invasive procedure; mediastinoscopy; fluorodeoxyglucose; video assisted thoracoscopic surgery; chemoradiotherapy; endoscopic echography; mediastinum metastasis; mediastinum lymph node; randomized controlled trial (topic); clinical trial (topic); diagnostic test accuracy study |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 10 |
| Issue: | 5 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2012-05-01 |
| Start Page: | 599 |
| End Page: | 613 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 22570291 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 July 2012" - "Source: Scopus" |
