Advanced well-differentiated/dedifferentiated liposarcomas: Role of chemotherapy and survival Journal Article
| Authors: | Italiano, A.; Toulmonde, M.; Cioffi, A.; Penel, N.; Isambert, N.; Bompas, E.; Duffaud, F.; Patrikidou, A.; Lortal, B.; Le Cesne, A.; Blay, J. Y.; Maki, R. G.; Schwartz, G. K.; Antonescu, C. R.; Singer, S.; Coindre, J. M.; Bui, B. |
| Article Title: | Advanced well-differentiated/dedifferentiated liposarcomas: Role of chemotherapy and survival |
| Abstract: | Background: Data regarding the role of systemic therapy in patients with advanced well-differentiated/dedifferentiated liposarcomas (WDLPS/DDLPS) are limited. Methods: From 2000 to 2010, 208 patients with advanced WDLPS/DDLPS received chemotherapy in 11 participating institutions. Clinical and pathological data were collected by reviewing medical records. Results: Median age was 63 years (range 32-84). Combination chemotherapy was delivered in 85 cases (41%) and single agent in 123 cases (59%), respectively. One hundred and seventy-one patients (82%) received an anthracycline-containing regimen. Using RECIST, objective response was observed in 21 patients (12%), all treated with anthracyclines. Median progression-free survival (PFS) was 4.6 months [95% confidence interval (CI) 3.3-5.9]. On multivariate analysis, age and performance status (PS) were the sole factors significantly associated with poor PFS. Median overall survival (OS) was 15.2 months (95% CI 11.8-18.7). On multivariate analysis, grade and PS were the sole factors significantly associated with OS. Conclusions: Chemotherapy was associated with clinical benefit in 46% of patients with advanced WDLPS/DDLPS. OS remains poor, even though visceral metastatic disease is less frequent than in other sarcomas. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. |
| Keywords: | chemotherapy; treatment; liposarcoma; dedifferentiated liposarcomas; well-differentiated liposarcomas |
| Journal Title: | Annals of Oncology |
| Volume: | 23 |
| Issue: | 6 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2012-06-01 |
| Start Page: | 1601 |
| End Page: | 1607 |
| Language: | English |
| DOI: | 10.1093/annonc/mdr485 |
| PROVIDER: | scopus |
| PUBMED: | 22039081 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 July 2012" - "CODEN: ANONE" - "Source: Scopus" |
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