Factors associated with relapse and survival in Wilms tumor: A multivariate analysis Journal Article
| Authors: | Honeyman, J. N.; Rich, B. S.; McEvoy, M. P.; Knowles, M. A.; Heller, G.; Riachy, E.; Kobos, R.; Shukla, N.; Wolden, S. L.; Steinherz, P. G.; La Quaglia, M. P. |
| Article Title: | Factors associated with relapse and survival in Wilms tumor: A multivariate analysis |
| Abstract: | Purpose: Lymph node metastasis and anaplasia predict relapse-free survival in Wilms tumor. We performed a multivariate analysis of our institutional database to identify factors independently associated with relapse-free and overall survival. Methods: We retrospectively reviewed cases of confirmed Wilms tumor diagnosed between 1990 and 2010 and treated at our institution. The log-rank test was used to screen variables for consideration in the proportional hazards model. Results: A total of 95 patients were treated at our institution during the study period, with a median follow-up of 3.3 years. Factors correlated with overall survival in the univariate analysis were local disease, metastasis, tumor size, anaplasia, renal vein tumor thrombus, inferior vena cava tumor thrombus, lymph node positivity, and tumor rupture. On multivariate analysis, factors associated with increased risk of death were lymph node positivity and anaplasia. Factors correlated with probability of relapse in the univariate analysis were lymph node positivity, anaplasia, and female sex. All 3 of these factors were also independently significant on multivariate analysis. Conclusion: Lymph node involvement and anaplasia are significantly correlated with probability of relapse and overall survival, reemphasizing the strong recommendation to sample regional lymph nodes during Wilms tumor resection. © 2012 Elsevier Inc. All rights reserved. |
| Keywords: | adolescent; adult; cancer chemotherapy; cancer survival; child; preschool child; school child; disease-free survival; retrospective studies; major clinical study; overall survival; cancer recurrence; conference paper; cancer radiotherapy; follow-up studies; lymph node metastasis; antineoplastic agent; lymphatic metastasis; metastasis; tumor volume; proportional hazards models; risk factors; retrospective study; kidney carcinoma; kidney neoplasms; nephrectomy; infant; tumor burden; newborn; new york city; multivariate analysis; inferior cava vein; anaplastic carcinoma; nephroblastoma; kidney vein thrombosis; renal veins; vena cava, inferior; recurrence free survival; tumor thrombus; kaplan-meier estimate; scoliosis; wilms tumor; venous thrombosis; cancer prognosis |
| Journal Title: | Journal of Pediatric Surgery |
| Volume: | 47 |
| Issue: | 6 |
| ISSN: | 0022-3468 |
| Publisher: | W.B. Saunders Co-Elsevier Inc. |
| Date Published: | 2012-06-01 |
| Start Page: | 1228 |
| End Page: | 1233 |
| Language: | English |
| DOI: | 10.1016/j.jpedsurg.2012.03.030 |
| PROVIDER: | scopus |
| PUBMED: | 22703798 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 July 2012" - "CODEN: JPDSA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work