Evidence-based treatment of delirium in patients with cancer Journal Article


Authors: Breitbart, W.; Alici, Y.
Article Title: Evidence-based treatment of delirium in patients with cancer
Abstract: Delirium is the most common neuropsychiatric complication seen in patients with cancer, and it is associated with significant morbidity and mortality. Increased health care costs, prolonged hospital stays, and long-term cognitive decline are other well-recognized adverse outcomes of delirium. Improved recognition of delirium and early treatment are important in diminishing such morbidity. There has been an increasing number of studies published in the literature over the last 10 years regarding delirium treatment as well as prevention. Antipsychotics, cholinesterase inhibitors, and alpha-2 agonists are the three groups of medications that have been studied in randomized controlled trials in different patient populations. In patients with cancer, the evidence is most clearly supportive of short-term, low-dose use of antipsychotics for controlling the symptoms of delirium, with close monitoring for possible adverse effects, especially in older patients with multiple medical comorbidities. Nonpharmacologic interventions also appear to have a beneficial role in the treatment of patients with cancer who have or are at risk for delirium. This article presents evidence-based recommendations based on the results of pharmacologic and nonpharmacologic studies of the treatment and prevention of delirium.
Keywords: review; neoplasm; neoplasms; delirium; prevalence; evidence based practice; evidence-based practice; psychological aspect; neuroleptic agent; antipsychotic agents; cholinesterase inhibitor; cholinesterase inhibitors; alpha 2 adrenergic receptor stimulating agent; adrenergic alpha-2 receptor agonists
Journal Title: Journal of Clinical Oncology
Volume: 30
Issue: 11
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2012-04-10
Start Page: 1206
End Page: 1214
Language: English
DOI: 10.1200/jco.2011.39.8784
PUBMED: 22412123
PROVIDER: scopus
PMCID: PMC3646320
DOI/URL:
Notes: --- - "Export Date: 2 July 2012" - "Source: Scopus"
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MSK Authors
  1. William S Breitbart
    338 Breitbart
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