miR than meets the eye Journal Article
| Authors: | Sage, J.; Ventura, A. |
| Article Title: | miR than meets the eye |
| Abstract: | Retinoblastoma is a rare pediatric cancer that has served as a paradigm to investigate the mechanisms of tumorigen-esis. In this issue of Genes & Development, Conkrite and colleagues (pp. 1734-1745) found high levels of the miR-17~92 and miR-106b-25 microRNAs in primary retino-blastomas and show that overexpression of miR-17~92 accelerates retinoblastoma development in mice by promoting proliferation, in part by reducing expression of the cell cycle inhibitor p21. These experiments identify the RB/miR-17~92/p21 axis as a critical regulator of retinoblastoma tumorigenesis and potentially many other cancers. © 2011 by Cold Spring Harbor Laboratory Press. |
| Keywords: | signal transduction; protein expression; unclassified drug; gene mutation; gene deletion; mutation; pathogenesis; nonhuman; cell proliferation; animals; gene targeting; mus; cell cycle progression; gene overexpression; apoptosis; microrna; gene amplification; genetic transcription; retinoblastoma; carcinogenesis; colon cancer; transcription factor e2f; myc protein; medulloblastoma; retina; pregnancy; upregulation; gene regulatory network; large cell lymphoma; gene dosage; micrornas; cyclin dependent kinase; retinoblastoma protein; protein p21; protein p107; protein p130; transcription factor e2f1; chromatin assembly and disassembly; rb; mir-17~92; mir 17 92; retina development |
| Journal Title: | Genes and Development |
| Volume: | 25 |
| Issue: | 16 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2011-08-15 |
| Start Page: | 1663 |
| End Page: | 1667 |
| Language: | English |
| DOI: | 10.1101/gad.17454011 |
| PUBMED: | 21852531 |
| PROVIDER: | scopus |
| PMCID: | PMC3165930 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 June 2012" - "CODEN: GEDEE" - "Source: Scopus" |
