miR than meets the eye Journal Article


Authors: Sage, J.; Ventura, A.
Article Title: miR than meets the eye
Abstract: Retinoblastoma is a rare pediatric cancer that has served as a paradigm to investigate the mechanisms of tumorigen-esis. In this issue of Genes & Development, Conkrite and colleagues (pp. 1734-1745) found high levels of the miR-17~92 and miR-106b-25 microRNAs in primary retino-blastomas and show that overexpression of miR-17~92 accelerates retinoblastoma development in mice by promoting proliferation, in part by reducing expression of the cell cycle inhibitor p21. These experiments identify the RB/miR-17~92/p21 axis as a critical regulator of retinoblastoma tumorigenesis and potentially many other cancers. © 2011 by Cold Spring Harbor Laboratory Press.
Keywords: signal transduction; protein expression; unclassified drug; gene mutation; gene deletion; mutation; pathogenesis; nonhuman; cell proliferation; animals; gene targeting; mus; cell cycle progression; gene overexpression; apoptosis; microrna; gene amplification; genetic transcription; retinoblastoma; carcinogenesis; colon cancer; transcription factor e2f; myc protein; medulloblastoma; retina; pregnancy; upregulation; gene regulatory network; large cell lymphoma; gene dosage; micrornas; cyclin dependent kinase; retinoblastoma protein; protein p21; protein p107; protein p130; transcription factor e2f1; chromatin assembly and disassembly; rb; mir-17~92; mir 17 92; retina development
Journal Title: Genes and Development
Volume: 25
Issue: 16
ISSN: 0890-9369
Publisher: Cold Spring Harbor Laboratory Press  
Date Published: 2011-08-15
Start Page: 1663
End Page: 1667
Language: English
DOI: 10.1101/gad.17454011
PUBMED: 21852531
PROVIDER: scopus
PMCID: PMC3165930
DOI/URL:
Notes: --- - "Export Date: 4 June 2012" - "CODEN: GEDEE" - "Source: Scopus"
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  1. Andrea Ventura
    56 Ventura