Screening for germline EGFR T790M mutations through lung cancer genotyping Journal Article
| Authors: | Oxnard, G. R.; Miller, V. A.; Robson, M. E.; Azzoli, C. G.; Pao, W.; Ladanyi, M.; Arcila, M. E. |
| Article Title: | Screening for germline EGFR T790M mutations through lung cancer genotyping |
| Abstract: | INTRODUCTION:: The study of patients carrying germline endothelial growth factor receptor (EGFR) mutations, which have been found in cases of familial lung adenocarcinoma, could provide unique insight into lung cancer risk and carcinogenesis in never-smokers. However, investigations into the biology of germline EGFR mutations have been hampered by the lack of an effective strategy for screening for carriers. We hypothesized that patients with lung cancers found to harbor the EGFR T790M resistance mutation before treatment, an uncommon occurrence, would be likely to carry underlying germline T790M mutations. METHODS:: Eleven unrelated patients with lung cancer, harboring an EGFR T790M mutation, were identified from a 7-year institutional experience with tumor genotyping. Ten patients had benign tissue available, which was anonymously tested for the presence of germline EGFR mutations. RESULTS:: Five of 10 cases carried a germline T790M mutation (50%, confidence interval 27%-73%). One patient's cancer exhibited a distinctive indolent growth, which has also been described in preclinical studies of T790M-mutant cancers. A second patient underwent resection of six separate primary lung adenocarcinomas, each carrying different sensitizing EGFR mutations and T790M. CONCLUSIONS:: Genotyping of lung cancers, now commonly performed to predict benefit from treatment with EGFR tyrosine kinase inhibitors, can also be used as a screening tool to identify patients at risk of carrying germline EGFR mutations. Once identified, these patients and their families can be studied prospectively to explore appropriate lung cancer screening strategies. Further studies using existing oncogenomic data to provide insight into underlying germline genetics are warranted. Copyright © 2012 by the International Association for the Study of Lung Cancer. |
| Keywords: | adult; clinical article; human tissue; middle aged; survival rate; unclassified drug; mutation; receptors, vascular endothelial growth factor; genetic predisposition to disease; lung neoplasms; incidence; genotype; risk factors; cancer screening; lung cancer; netherlands; lung adenocarcinoma; disease progression; genetic screening; germ-line mutation; genetic testing; growth factor receptor; endothelial growth factor receptor |
| Journal Title: | Journal of Thoracic Oncology |
| Volume: | 7 |
| Issue: | 6 |
| ISSN: | 1556-0864 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-06-01 |
| Start Page: | 1049 |
| End Page: | 1052 |
| Language: | English |
| DOI: | 10.1097/JTO.0b013e318250ed9d |
| PROVIDER: | scopus |
| PMCID: | PMC3354706 |
| PUBMED: | 22588155 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 June 2012" - "Source: Scopus" |
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