Synapse - Long-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant

Long-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant Journal Article

Authors:	Goldberg, J. D.; Chou, J. F.; Horwitz, S.; Teruya-Feldstein, J.; Barker, J. N.; Boulad, F.; Castro-Malaspina, H.; Giralt, S.; Jakubowski, A. A.; Koehne, G.; van den Brink, M. R. M.; Young, J. W.; Zhang, Z.; Papadopoulos, E. B.; Perales, M. A.
Article Title:	Long-term survival in patients with peripheral T-cell non-Hodgkin lymphomas after allogeneic hematopoietic stem cell transplant
Abstract:	Peripheral T-cell non-Hodgkin lymphomas (T-NHL) are rare diseases, with a worse prognosis compared to their B-cell counterparts. Allogeneic hematopoietic stem cell transplant may have a role in the treatment of relapsed/refractory disease or high-risk histologies in the upfront setting. However, there is limited information on the efficacy of allogeneic transplant for these diseases, as well as what factors may predict outcomes. We therefore performed a retrospective study of 34 patients who received an allogeneic transplant for the treatment of T-NHL at a single center between 1 January 1992 and 31 December 2009. The median follow-up for survivors was 45 months (range 9160 months). The 2-year overall survival (OS) was 0.61 (95% confidence interval [CI]: 0.430.75) with a plateau at 28 months. Ki-67 expression ≤ 25% was predictive of improved OS (p < 0.01), and transplant in complete remission was predictive of a decreased cumulative incidence of events (p 0.04). Three patients received a donor leukocyte infusion, and two patients demonstrated a response, supporting a graft-versus-lymphoma effect. These data demonstrate that allogeneic transplant is a viable option for the treatment of T-NHL and merits prospective evaluation. © 2012 Informa UK, Ltd.
Keywords:	adolescent; adult; child; clinical article; preschool child; protein expression; school child; aged; child, preschool; middle aged; survival analysis; retrospective studies; transplantation, homologous; young adult; overall survival; follow up; ki 67 antigen; infection; hematopoietic stem cell transplantation; time factors; survivors; cancer regression; graft failure; nonhodgkin lymphoma; lymphoma, non-hodgkin; graft versus host reaction; donor lymphocyte infusion; allogeneic hematopoietic stem cell transplantation; multiple organ failure; lymphoma, t-cell, peripheral; allogeneic hsct; graft-versus-lymphoma effect; t-cell non-hodgkin lymphoma; graft versus lymphoma effect; t cell non hodgkin lymphoma
Journal Title:	Leukemia and Lymphoma
Volume:	53
Issue:	6
ISSN:	1042-8194
Publisher:	Taylor & Francis Group
Date Published:	2012-06-01
Start Page:	1124
End Page:	1129
Language:	English
DOI:	10.3109/10428194.2011.645818
PROVIDER:	scopus
PUBMED:	22136377
PMCID:	PMC4054938
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84861407524&partnerID=40&md5=a5fb322489803bd3935eee6b9e72ad1d
Notes:	--- - "Export Date: 4 June 2012" - "CODEN: LELYE" - "Source: Scopus"