Long term renal toxicity of ifosfamide in adult patients - 5 year data Journal Article
| Authors: | Farry, J. K.; Flombaum, C. D.; Latcha, S. |
| Article Title: | Long term renal toxicity of ifosfamide in adult patients - 5 year data |
| Abstract: | Ifosfamide is indicated as first line treatment in a variety of solid tumours in adults. It is known to be nephrotoxic and is often used following therapy with, or as concomitant therapy with other potent nephrotoxins. To date, there are sparse case reports on the incidence of acute kidney injury (AKI) or chronic kidney disease (CKD) in adults exposed to ifosfamide. The available data on the long term renal complications for patients exposed to ifosfamide are thus based entirely on the paediatric population. The aim of this study was to assess the long term effects of ifosfamide exposure on renal function in an adult population and to determine if there are any treatment or patient specific factors that contribute to long term nephrotoxicity. The mean decline in estimated glomerular filtration rate (eGFR) following the first cycle of ifosfamide was 15 ml/min/1.73 m 2. Thereafter, there was a slower but steady decline in eGFR. No patient progressed to end stage renal disease (ESRD). Patient age and concomitant exposure to carboplatin were the only two factors which significantly affected eGFR. This represents the only long term study on the nephrotoxicity of ifosfamide in adults. © 2011 Elsevier Ltd. All rights reserved. |
| Keywords: | adolescent; adult; aged; middle aged; retrospective studies; young adult; major clinical study; drug megadose; carboplatin; nephrotoxicity; aciclovir; kidney failure; age factors; drug effect; ifosfamide; time; kidney; kidney function; nonsteroid antiinflammatory agent; antineoplastic agents, alkylating; long term care; glomerular filtration rate; glomerulus filtration rate; drug exposure; aminoglycoside; acute kidney injury; long term nephrotoxicity; renal complications; amphotericin |
| Journal Title: | European Journal of Cancer |
| Volume: | 48 |
| Issue: | 9 |
| ISSN: | 0959-8049 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2012-01-01 |
| Start Page: | 1326 |
| End Page: | 1331 |
| Language: | English |
| DOI: | 10.1016/j.ejca.2012.03.009 |
| PROVIDER: | scopus |
| PUBMED: | 22503397 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 4 June 2012" - "CODEN: EJCAE" - "Source: Scopus" |
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