Lung cancer: Computerized quantification of tumor response - Initial results Journal Article

Authors: Zhao, B.; Schwartz, L. H.; Moskowitz, C. S.; Ginsberg, M. S.; Rizvi, N. A.; Kris, M. G.
Article Title: Lung cancer: Computerized quantification of tumor response - Initial results
Abstract: Purpose: To prospectively quantify tumor response or progression in patients with lung cancer by using thin-section computed tomography (CT) and a semiautomated algorithm to calculate tumor volume and other parameter values. Materials and Methods: This HIPAA-compliant study was institutional review board approved; informed patient consent was waived. CT scans of 15 measurable non-small cell lung cancers (in five men and 10 women; mean age, 64 years; range, 38-78 years) before and after gefitinib treatment were analyzed. A semiautomated three-dimensional lung cancer segmentation algorithm was developed and applied to each tumor at baseline and follow-up. The computer calculated the greatest diameter (unidimensional measurement), the product of the greatest diameter and the greatest perpendicular diameter (bidimensional measurement), and the volume of each tumor. Exact McNemar tests were used to analyze differences in the percentage change calculated with different measurement techniques. Results: The computer accurately segmented 14 of the 15 tumors. One paramediastinal tumor required manual separation from the mediastinum. Eleven (73%) of the 15 patients had an absolute change in tumor volume of at least 20%, compared with one (7%) and four (27%) patients who had similar changes in unsealed unidimensional (P < .01) and bidimensional (P = .04) tumor measurements, respectively. Seven (47%) patients had an absolute change in tumor volume of at least 30%. In contrast, at unsealed analysis, no patients at unidimensional measurement (P = .02) and two (13%) patients at bidimensional measurement (P = .06) had a change of at least 30%. Conclusion: Compared with the unidimensional and bidimensional techniques, semiautomated tumor segmentation enabled the identification of a larger number of patients with absolute changes in tumor volume of at least 20% and 30%. © RSNA, 2006.
Keywords: adult; cancer chemotherapy; clinical article; treatment outcome; aged; middle aged; clinical trial; follow up; cancer diagnosis; prospective studies; computer assisted tomography; tumor volume; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; lung cancer; tomography, x-ray computed; algorithms; imaging system; algorithm; tumor burden; disease progression; three dimensional imaging; gefitinib; statistics, nonparametric; image reconstruction; radiographic image interpretation, computer-assisted; multidetector computed tomography; computed tomography scanner
Journal Title: Radiology
Volume: 241
Issue: 3
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 2006-12-01
Start Page: 892
End Page: 898
Language: English
DOI: 10.1148/radiol.2413051887
PUBMED: 17114630
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 37" - "Export Date: 4 June 2012" - "CODEN: RADLA" - "Source: Scopus"
Altmetric Score
MSK Authors
  1. Michelle S Ginsberg
    159 Ginsberg
  2. Lawrence H Schwartz
    281 Schwartz
  3. Binsheng Zhao
    46 Zhao
  4. Naiyer A Rizvi
    157 Rizvi
  5. Chaya S. Moskowitz
    173 Moskowitz
  6. Mark Kris
    612 Kris