| Abstract: |
Biologically conformal radiation therapy (BCRT), a convergence of intensity-modulated radiation therapy (IMRT) and positron emission tomography (PET)-based functional imaging, incorporates patient-specific, image-derived biological information. This approach may potentially lead to a paradigm shift in radiation therapy - spatially varying dose prescriptions, or dose sculpting, for individualized and dosimetrically optimized treatment. This article reviews the current status of the technical, biological, and clinical aspects of PET-guided radiation therapy. It remains unclear, however, whether PET is currently capable of delineating the true extent of viable tumor with sufficient accuracy and precision to reliably guide therapy on a routine basis. © 2006 by Begell House, Inc. |
| Keywords: |
unclassified drug; myeloproliferative disorder; review; intensity modulated radiation therapy; iodinated poppyseed oil; nonhuman; treatment planning; unspecified side effect; bone metastasis; cancer radiotherapy; radiation dose; positron emission tomography; cancer diagnosis; diagnostic accuracy; sensitivity and specificity; neoplasms; accuracy; unindexed drug; cancer immunotherapy; biology; radiation; tumor volume; lung cancer; cancer pain; neuroendocrine tumor; prostate cancer; hypoxia; prescription; radiotherapy, intensity-modulated; dosimetry; liver tumor; fluorodeoxyglucose f 18; computer assisted emission tomography; positron-emission tomography; radiopharmaceutical agent; brachytherapy; imaging; radiation therapy; thyroid cancer; meningioma; external beam radiotherapy; maximum tolerated dose; (3 iodobenzyl)guanidine i 131; hyperthyroidism; radioimmunotherapy; computer assisted radiotherapy; pheochromocytoma; single photon emission computer tomography; indium 111; bioinformatics; 3' fluorothymidine f 18; acetic acid c 11; lipid metabolism; glycolysis; positron emission tomography (pet); pentetreotide in 111; thyroid disease; leptomeninx; yttrium 90; lexidronam samarium sm 153; strontium 89; intensity-modulated radiation therapy (imrt); rhenium 188; chromium 51; three-dimensional conformal radiation therapy (3dcrt); 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetramethylene phosphonate ho 166; 2 fluorophenylalanine f 18; 2 fluorotyrosine f 18; 3 fluoro alpha methyltyrosine f 18; 6 fluorodihydroxyphenylalanine f 18; bromodeoxyuridine br 76; chromium phosphate p 32; clevudine; erbium 169; etidronic acid re 186; hydroxyapatite sm 153; iodoxyuridine i 124; o 2 fluoroethyltyrosine f 18; pentetate tin sn 117m; phosphate p 32; sodium iodide i 131
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