To be or not to be B7 Journal Article
| Authors: | Zang, X.; Allison, J. P. |
| Article Title: | To be or not to be B7 |
| Abstract: | The activation of lymphocytes and development of adaptive immune responses is initiated by the engagement of TCRs by antigenic peptide-MHC complexes and shaped at the clonal level by both positive and negative costimulatory signals. The B7 family members are involved at several stages in this process. In this issue of the JCI, Vogt et al. show that the B7 family-related protein V-set and Ig domain-containing 4 (VSIG4) can act as an inhibitor of T cell activation (see the related article beginning on page 2817). Intriguingly, the same molecule was recently independently identified as a complement receptor of the Ig superfamily (CRIg) and was convincingly demonstrated to be a receptor for complement component 3 fragments. These findings raise interesting questions regarding the physiological roles and mechanisms of action of this molecule. Identification of dual functions of this molecule provides an additional level of complexity in T cell costimulation. |
| Keywords: | signal transduction; protein expression; unclassified drug; review; t lymphocyte; t-lymphocytes; animals; mice; gene expression; evolution; evolution, molecular; t lymphocyte receptor; lymphocyte activation; immune response; major histocompatibility complex; b7 antigen; immunoglobulins; models, immunological; complement receptor; complement component c3; protein complement receptor ig; protein vsig4; receptors, complement; receptors, complement 3b |
| Journal Title: | Journal of Clinical Investigation |
| Volume: | 116 |
| Issue: | 10 |
| ISSN: | 0021-9738 |
| Publisher: | American Society for Clinical Investigation |
| Date Published: | 2006-10-02 |
| Start Page: | 2590 |
| End Page: | 2593 |
| Language: | English |
| DOI: | 10.1172/jci30103 |
| PUBMED: | 17016555 |
| PROVIDER: | scopus |
| PMCID: | PMC1578606 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 4 June 2012" - "CODEN: JCINA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work