Combination gene therapy with p53 and Thoc1/p84 is more effective than either single agent in an animal model of human pancreatic adenocarcinoma Journal Article


Authors: Yin, S.; Goodrich, D. W.
Article Title: Combination gene therapy with p53 and Thoc1/p84 is more effective than either single agent in an animal model of human pancreatic adenocarcinoma
Abstract: Gene therapy utilizing tumor suppressor gene p53 has been tested in a number of cancers in both preclinical models and clinical trials. Despite the ability of p53 to significantly inhibit tumor growth in preclinical models, it has met with more limited clinical success. This is due, in part, to the observation that a substantial fraction of tumors are resistant to the effects of p53 expression. We have tested whether combination therapy with Thoc1/p84 and p53 is more effective than single gene therapy in a p53-resistant tumor model of human pancreatic adenocarcinoma. Infection with Thoc1/p84 and p53 adenovirus inhibits pancreatic cancer cell growth in vitro and in vivo to a greater extent than treatment with either one alone at the same total viral dose. Similar results are observed with Thoc1/p84 and Rb1 gene therapy. The data support the use of therapy that targets both the p53 and Thoc1/p84 pathways in tumors that are resistant to perturbation of the p53 pathway alone.
Keywords: apoptosis; gene therapy; pancreatic adenocarcinoma; retinoblastoma gene
Journal Title: International Journal of Oncology
Volume: 28
Issue: 3
ISSN: 1019-6439
Publisher: Spandidos Publications  
Date Published: 2006-03-01
Start Page: 781
End Page: 785
Language: English
PROVIDER: scopus
PUBMED: 16465385
DOI/URL:
Notes: --- - "Cited By (since 1996): 3" - "Export Date: 4 June 2012" - "CODEN: IJONE" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Shenmin Yin
    4 Yin