Favorable clinical outcomes of three-dimensional computer-optimized high-dose-rate prostate brachytherapy in the management of localized prostate cancer Journal Article
| Authors: | Yamada, Y.; Bhatia, S.; Zaider, M.; Cohen, G.; Donat, M.; Eastham, J.; Rabbani, F.; Schupak, K.; Lee, J.; Mueller, B.; Zelefsky, M. J. |
| Article Title: | Favorable clinical outcomes of three-dimensional computer-optimized high-dose-rate prostate brachytherapy in the management of localized prostate cancer |
| Abstract: | Purpose: To report PSA relapse-free survival and toxicity outcomes of prostate cancer patients who have undergone three-dimensional computer-optimized high-dose-rate (HDR) brachytherapy with external beam radiotherapy as definitive treatment. Methods and materials: One hundred five patients consecutively treated between 1998 and 2004 are reported. All patients were treated with HDR boost with lr 192 (5.5-7.0 Gy), based upon postimplant CT three-dimensional treatment planning using an in-house treatment plan optimization algorithm. Three-dimensional conformal external beam radiotherapy (45-50.4 Gy) was also administered 3 weeks after the HDR procedure. Toxicity was measured using National Cancer Institutes Common Toxicity Criteria and International Prostate Symptom Score indices. Results: With a median followup of 44 months (8-79 months), the 5-year PSA relapse-free survival outcomes for low, intermediate and high-risk patients were 100%, 98%, and 92%, respectively, Median urinary toxicity, and 93% of patients denied rectal problems at the time of last followup. Erectile dysfunction was noted in 47% patients at the time of last followup, but overall 80% were able to achieve vaginal penetration when those who responded to sildenafil were included. Conclusion: Computer-optimized three-dimensional HDR prostate brachytherapy provides excellent disease control for even high risk localized prostate cancer. Significant toxicity has been minimal. © 2006 American Brachytherapy Society. |
| Keywords: | adult; cancer survival; treatment outcome; aged; middle aged; implant; retrospective studies; major clinical study; cancer localization; cancer risk; treatment planning; cancer radiotherapy; radiation dose; follow-up studies; computer assisted tomography; tomography, x-ray computed; time factors; dose-response relationship, radiation; prostate cancer; prostatic neoplasms; algorithm; imaging, three-dimensional; urinary frequency; brachytherapy; cancer relapse; radiotherapy planning, computer-assisted; external beam radiotherapy; disease control; erectile dysfunction; sildenafil; prostate brachytherapy; high dose rate; urinary dysfunction; rectum disease; computer optimized |
| Journal Title: | Brachytherapy |
| Volume: | 5 |
| Issue: | 3 |
| ISSN: | 1538-4721 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2006-07-01 |
| Start Page: | 157 |
| End Page: | 164 |
| Language: | English |
| DOI: | 10.1016/j.brachy.2006.03.004 |
| PUBMED: | 16864067 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 24" - "Export Date: 4 June 2012" - "CODEN: BRACC" - "Source: Scopus" |
