Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol Journal Article
| Authors: | Wu, B.; Chen, J.; Warren, J. D.; Chen, G.; Hua, Z.; Danishefsky, S. J. |
| Article Title: | Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol |
| Abstract: | (Figure Presented) The missing link: Reiterative ligations based on non-cysteine and cysteine-based acyl acceptors have been used to prepare synthetic polypeptides and proteins with multiple sites of glycosylation. Highly complex positionally defined glycopolypeptides corresponding to single glycoforms can be formed from simple components. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA. |
| Keywords: | proteins; erythropoietin; chemistry; peptides; models, molecular; chemical structure; molecular structure; catalysis; glycoproteins; synthesis; glycopeptide; glycopeptides; cysteine; native chemical ligation; complexation; polypeptides; cysteine-free ligation |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 45 |
| Issue: | 25 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2006-06-19 |
| Start Page: | 4116 |
| End Page: | 4125 |
| Language: | English |
| DOI: | 10.1002/anie.200600538 |
| PUBMED: | 16710874 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 74" - "Export Date: 4 June 2012" - "CODEN: ACIEA" - "Source: Scopus" |
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