Control of stereoselectivity in an enzymatic reaction by backdoor access Journal Article
| Authors: | Wombacher, R.; Keiper, S.; Suhm, S.; Serganov, A.; Patel, D. J.; Jäschke, A. |
| Article Title: | Control of stereoselectivity in an enzymatic reaction by backdoor access |
| Abstract: | (Figure Presented) Sneaking in: The active site of a Diels-Alder ribozyme features two different "doors" through which the diene may enter. Depending on which door is used, either of the two enantiomeric Diels-Alder products is synthesized selectively. Enantioselectivity can be modulated by controlling access to the ribozyme's active site. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA. |
| Keywords: | metabolism; chemistry; substrate specificity; models, molecular; protein structure, tertiary; chemical structure; catalysis; enzyme specificity; protein tertiary structure; olefins; synthesis (chemical); stereoisomerism; cycloaddition; enantioselectivity; ribozyme; reaction kinetics; rna, catalytic; enzyme immobilization; enzyme catalysis; ribozymes; aromatic compounds |
| Journal Title: | Angewandte Chemie - International Edition |
| Volume: | 45 |
| Issue: | 15 |
| ISSN: | 1433-7851 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2006-04-03 |
| Start Page: | 2469 |
| End Page: | 2472 |
| Language: | English |
| DOI: | 10.1002/anie.200503280 |
| PUBMED: | 16528762 |
| PROVIDER: | scopus |
| PMCID: | PMC4693636 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 4 June 2012" - "CODEN: ACIEA" - "Source: Scopus" |
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