Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer Journal Article
| Authors: | Thompson, R. H.; Allison, J. P.; Kwon, E. D. |
| Article Title: | Anti-cytotoxic T lymphocyte antigen-4 (CTLA-4) immunotherapy for the treatment of prostate cancer |
| Abstract: | Costimulatory pathway ligands and receptors can deliver either positive or negative signals to help determine the ultimate fate of activated T lymphocytes. Cytotoxic T lymphocyte antigen-4 (CTLA-4) represents one of the most extensively studied receptors in the costimulatory pathway and has recently been shown to function as a potent inhibitor of T cell-mediated immunity. T-cell expression of CTLA-4 indirectly facilitates tumor progression by restraining host antitumoral immunity. In contrast, administration of a monoclonal antibody to block CTLA-4 function can alleviate restraints on T-cell activity to promote immune-mediated tumor regression. We review the preclinical and clinical experience with CTLA-4 blockade as a promising immunotherapeutic approach to treat patients with advanced prostate cancer. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | unclassified drug; clinical trial; drug tolerability; review; hepatitis; nonhuman; rituximab; phenotype; animals; ipilimumab; cancer immunotherapy; melanoma; steroid; drug potency; transgenic mouse; monoclonal antibody; prostate cancer; prostatic neoplasms; b cell lymphoma; t lymphocyte receptor; antibodies, monoclonal; immunotherapy; genetic engineering; breast carcinoma; large cell lymphoma; ctla-4; antigens, cd; tumor cell vaccine; cytotoxic t lymphocyte antigen 4; autoimmune disease; t lymphocyte activation; antigens, differentiation; enterocolitis; costimulation; hypophysitis; t-lymphocyte; ctla 4 antibody; trastizumab |
| Journal Title: | Urologic Oncology: Seminars and Original Investigations |
| Volume: | 24 |
| Issue: | 5 |
| ISSN: | 1078-1439 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-09-01 |
| Start Page: | 442 |
| End Page: | 447 |
| Language: | English |
| DOI: | 10.1016/j.urolonc.2005.08.011 |
| PUBMED: | 16962497 |
| PROVIDER: | scopus |
| PMCID: | PMC1976273 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 23" - "Export Date: 4 June 2012" - "CODEN: UOSOA" - "Source: Scopus" |
