Paclitaxel and carboplatin in the adjuvant treatment of patients with high-risk stage III and IV endometrial cancer: A retrospective study Journal Article
| Authors: | Sovak, M. A.; Hensley, M. L.; Dupont, J.; Ishill, N.; Alektiar, K. M.; Abu Rustum, N.; Barakat, R.; Chi, D. S.; Sabbatini, P.; Spriggs, D. R.; Aghajanian, C. |
| Article Title: | Paclitaxel and carboplatin in the adjuvant treatment of patients with high-risk stage III and IV endometrial cancer: A retrospective study |
| Abstract: | Purpose.: To determine overall survival and progression-free survival among patients with high-risk, stage III and IV endometrial cancer who receive paclitaxel and carboplatin (TC) after complete tumor resection. Patients and methods.: Patients with stage III/IV endometrial cancer with less than 2 cm of disease after surgical resection who received TC in the adjuvant setting were retrospectively identified and are the subject of this analysis. Data were extracted from electronic medical records. Disease recurrence was documented by radiologic progression or pathologic tissue review. We obtained Institutional Review Board approval before initiating this study. Results.: Forty-eight patients were eligible for analysis-24 (50%) with stage IV disease, 29 (60%) with serous or clear cell tumor histology and 43 (90%) with FIGO grade 3 tumors. All patients underwent surgical resection; 10 (21%) of the 48 patients received adjuvant radiation therapy in addition to chemotherapy. Forty-three patients (90%) received 6 cycles of paclitaxel (175 mg/m2) and carboplatin (area under the curve of 5-6) every 3 or 4 weeks, and 44 (92%) completed all planned cycles of treatment. With a median follow-up of 20 months (range, 6-92), 29 patients (60%) recurred, with a 3-year overall survival rate of 56%. The median time to progression for all patients was 13 months (95% CI 10, 18) with a median OS of 47 months (95% CI, 30-upper limit not achieved). Conclusion.: TC is a well tolerated, active regimen in the treatment of resected, high-risk stage III and IV endometrial cancer that warrants further investigation. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | adult; cancer survival; clinical article; controlled study; human tissue; treatment outcome; aged; aged, 80 and over; disease-free survival; middle aged; cancer surgery; retrospective studies; histopathology; cancer recurrence; cancer growth; paclitaxel; adjuvant therapy; cancer adjuvant therapy; cancer radiotherapy; chemotherapy, adjuvant; cancer staging; neurotoxicity; follow up; endometrial cancer; hysterectomy; endometrial neoplasms; neoplasm staging; cancer grading; endometrium cancer; carboplatin; ovariectomy; retrospective study; high risk patient; drug hypersensitivity; medical record; clear cell carcinoma |
| Journal Title: | Gynecologic Oncology |
| Volume: | 103 |
| Issue: | 2 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-11-01 |
| Start Page: | 451 |
| End Page: | 457 |
| Language: | English |
| DOI: | 10.1016/j.ygyno.2006.03.019 |
| PUBMED: | 16677690 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 24" - "Export Date: 4 June 2012" - "CODEN: GYNOA" - "Source: Scopus" |
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