Activities and accomplishments of the Cancer and Leukemia Group B Genitourinary Committee Journal Article
| Authors: | Small, E. J.; Halabi, S.; Kantoff, P.; D'Amico, A.; Stadler, W.; Kelley, W. K.; Mohler, J.; Bajorin, D.; Vogelzang, N. J. |
| Article Title: | Activities and accomplishments of the Cancer and Leukemia Group B Genitourinary Committee |
| Abstract: | The Cancer and Leukemia Group B Genitourinary (GU) Committee has developed a multidisciplinary approach to treatment of GU cancer and has integrated correlative science research into the major research themes of the GU Committee. In localized prostate cancer, trials have evaluated novel approaches in radiation therapy. For patients with recurrence after local therapy, a trial evaluating local recurrence with salvage prostatectomy and a study of systemic therapy with "peripheral androgen blockade" were undertaken. Major contributions have been made in developing and testing therapeutics for advanced, androgen-independent prostate cancer (ketoconazole, suramin, estramustine/docetaxel, and docetaxel/bevacizumab), and in developing predictive markers and algorithms to assess prognosis in these patients. Contributions in kidney cancer have included the development of novel trial methodology, such as the randomized discontinuation trial design, and the testing of antiangiogenics. In addition to these areas, future work of the committee will include further development of therapy for earlier-stage prostate cancer patients and bladder cancer patients. © 2006 American Association for Cancer Research. |
| Keywords: | leukemia; unclassified drug; prednisone; clinical trial; review; cancer recurrence; angiogenesis inhibitor; bevacizumab; interferon; dose response; antineoplastic agents; neoplasms; carboplatin; radiotherapy; bladder cancer; cancer research; urogenital tract cancer; urinary bladder neoplasms; kidney carcinoma; kidney neoplasms; docetaxel; prostate cancer; urogenital neoplasms; prostatic neoplasms; drug research; carcinoma, renal cell; societies, medical; prostatectomy; mitoxantrone; finasteride; brachytherapy; flutamide; ketoconazole; kidney cancer; clinical trials; suramin; estramustine; carboxyaminoimadazole; sulindac sulfone |
| Journal Title: | Clinical Cancer Research |
| Volume: | 12 |
| Issue: | 11 Suppl. |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2006-06-01 |
| Start Page: | 3596s |
| End Page: | 3600s |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-06-9005 |
| PUBMED: | 16740791 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 4 June 2012" - "CODEN: CCREF" - "Source: Scopus" |
