Neuroendocrine differentiation in prostate cancer: A sheep in wolf's clothing? Journal Article
| Author: | Slovin, S. F. |
| Article Title: | Neuroendocrine differentiation in prostate cancer: A sheep in wolf's clothing? |
| Abstract: | Neuroendocrine differentiation of the prostate is often associated with a dismal prognosis. Whilst it is relatively rare compared with other forms of prostate cancer, it nevertheless remains difficult to treat these cancers effectively and to maintain a durable response. Research aimed at understanding the complexity of neuroendocrine differentiation of the prostate has been conducted for some time. The cells involved in this process secrete a variety of factors that can influence growth patterns and regulatory pathways. Many of these factors can be monitored serologically, but the relationship between the biology of the tumor and clinical response is often discordant. This review outlines the difficulties in treating this disease, both at the time of diagnosis and in the metastatic setting, and focuses on an area of research that remains challenging to both the researcher and clinician. © 2006 Nature Publishing Group. |
| Keywords: | neutropenia; review; cisplatin; doxorubicin; cancer combination chemotherapy; cancer risk; chemotherapy; cancer diagnosis; prostate specific antigen; carboplatin; gene expression; etoposide; mucosa inflammation; thrombocytopenia; gene function; cyclophosphamide; vincristine; cancer research; cancer therapy; vinblastine; risk assessment; irinotecan; prostate cancer; prostatic neoplasms; antigen detection; cancer cell; drug response; psa; interleukin 6; hormonal therapy; metastasis potential; gonadorelin agonist; taxane derivative; cancer classification; ethnic difference; serology; rare disease; carcinoma, neuroendocrine; chromogranin a; adrenalin; neuroendocrine differentiation; forskolin; neuroendocrinology |
| Journal Title: | Nature Clinical Practice Urology |
| Volume: | 3 |
| Issue: | 3 |
| ISSN: | 1743-4270 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2006-03-01 |
| Start Page: | 138 |
| End Page: | 144 |
| Language: | English |
| DOI: | 10.1038/ncpuro0435 |
| PUBMED: | 16528286 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 19" - "Export Date: 4 June 2012" - "Source: Scopus" |
