A retrospective analysis of the impact of 18F-FDG PET scans on clinical management of 133 breast cancer patients Journal Article
| Authors: | Santiago, J. F. Y.; Gonen, M.; Yeung, H.; Macapinlac, H.; Larson, S. |
| Article Title: | A retrospective analysis of the impact of 18F-FDG PET scans on clinical management of 133 breast cancer patients |
| Abstract: | Aim. While it is well-known that there is 18F-FDG uptake in breast tumors, clinical impact of 18F-FDG PET in managing breast cancer patients is not well-studied. Methods. One hundred and thirty-three consecutive breast cancer patients from May 1996 to June 2000 were studied. All patients were treated and being followed. Reasons of referral included equivocal conventional studies, staging/re-staging, clinical suspicion of recurrence, and elevated serum tumor markers. Clinical status at 6 months postPET is used as the gold standard in lesions of worsening versus stable or improving. Results. PET was 69% sensitive and 80% specific in predicting clinical stage at 6 months. This 69% of the patients who got worse at 6 months was PET positive and 80% of the patients who were stable or improving at 6 months were PET negative. There was a significant association between PET results and clinical outcome, after adjusting for stage of disease (P=0.04), or for the treatment patients received (P<0.01). Negative PET results changed therapy as often as positive ones did. PET influenced treatment decisions in 74% of the patients referred for study. Conclusion. PET holds promise as a sensitive and specific modality in following treated breast cancer patients. PET results contain information on 6 month outcome that is independent of stage or past treatment and influence patient management. |
| Keywords: | adult; controlled study; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; cancer recurrence; united states; cancer staging; positron emission tomography; follow up; antineoplastic agent; sensitivity and specificity; radiopharmaceuticals; physician's practice patterns; medical decision making; reproducibility of results; breast cancer; incidence; risk factors; breast neoplasms; retrospective study; tumor marker; risk assessment; disease severity; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; tomography, emission computed; patient referral; breast neoplasms, radionuclide imaging - fluodeoxyglucode, f18 |
| Journal Title: | Quarterly Journal of Nuclear Medicine and Molecular Imaging |
| Volume: | 50 |
| Issue: | 1 |
| ISSN: | 1824-4785 |
| Publisher: | Edizioni Minerva Medica |
| Date Published: | 2006-03-01 |
| Start Page: | 61 |
| End Page: | 67 |
| Language: | English |
| PUBMED: | 16557205 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 21" - "Export Date: 4 June 2012" - "CODEN: QJNMA" - "Source: Scopus" |
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