Endorectal MR imaging in the evaluation of seminal vesicle invasion: Diagnostic accuracy and multivariate feature analysis Journal Article

Authors: Sala, E.; Akin, O.; Moskowitz, C. S.; Eisenberg, H. F.; Kuroiwa, K.; Ishill, N. M.; Rajashanker, B.; Scardino, P. T.; Hricak, H.
Article Title: Endorectal MR imaging in the evaluation of seminal vesicle invasion: Diagnostic accuracy and multivariate feature analysis
Abstract: Purpose: To retrospectively determine the accuracy of endorectal magnetic resonance (MR) imaging in demonstrating seminal vesicle invasion (SVI) and to investigate the MR imaging features that can predict SVI. Materials and Methods: The Institutional Review Board granted exempt status for this retrospective study, with waiver of informed consent; patient data were collected and handled in accordance with HIPAA regulations. Fifty-one men (age range, 44-73 years) with SVI and 303 men (age range, 40-76 years) without SVI who underwent endorectal MR imaging before radical prostatectomy between January 2000 and October 2004 were included in the study. Endorectal MR images were retrospectively and independently analyzed by two radiologists for SVI, tumor at prostate base, extracapsular extension, and other features considered indicative of SVI. Areas under the receiver operating characteristic curves (AUCs) were used to assess the accuracy of detecting SVI at endorectal MR imaging. A multiple logistic regression was used to explore the combinations of MR imaging features that might facilitate the detection of SVI. Results: Readers 1 and 2 had an AUC of 0.93 and 0.81, respectively, for the detection of SVI. For both readers, the features that had the highest sensitivity and specificity were low signal intensity within the seminal vesicle and lack of preservation of seminal vesicle architecture. At multiple regression analysis, tumor at the prostate base that extended beyond the capsule and low signal intensity within a seminal vesicle that has lost its normal architecture were highly predictive of SVI. Conclusion: Endorectal MR imaging is accurate in demonstrating SVI prior to radical prostatectomy, and recognition of the most predictive features may facilitate the use of this modality. © RSNA, 2006.
Keywords: adult; human tissue; aged; middle aged; retrospective studies; major clinical study; area under the curve; conference paper; nuclear magnetic resonance imaging; magnetic resonance imaging; neoplasm staging; diagnostic accuracy; sensitivity and specificity; image analysis; logistic models; diagnostic imaging; retrospective study; prediction; prostate cancer; cancer invasion; prostatic neoplasms; diagnostic value; prostatectomy; multivariate logistic regression analysis; area under curve; cross-sectional studies; neoplasm invasiveness; seminal vesicle; statistics, nonparametric; signal detection; rectum; seminal vesicles; endorectal magnetic resonance imaging; apparatus
Journal Title: Radiology
Volume: 238
Issue: 3
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 2006-03-01
Start Page: 929
End Page: 937
Language: English
DOI: 10.1148/radiol.2383050657
PUBMED: 16424250
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 46" - "Export Date: 4 June 2012" - "CODEN: RADLA" - "Source: Scopus"
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MSK Authors
  1. Kentaro Kuroiwa
    28 Kuroiwa
  2. Evis Sala
    95 Sala
  3. Peter T Scardino
    621 Scardino
  4. Chaya S. Moskowitz
    173 Moskowitz
  5. Hedvig Hricak
    333 Hricak
  6. Oguz Akin
    179 Akin
  7. Nicole Marie Leoce
    86 Leoce