Percutaneous computerized tomography guided cryoablation for localized renal cell carcinoma: Factors influencing success Journal Article
| Authors: | Permpongkosol, S.; Link, R. E.; Kavoussi, L. R.; Solomon, S. B. |
| Article Title: | Percutaneous computerized tomography guided cryoablation for localized renal cell carcinoma: Factors influencing success |
| Abstract: | Purpose: We evaluated the factors that influenced the initial success rate and complication rate of percutaneous computerized tomography guided cryoablation of localized renal cell carcinoma of clinical stage T1N0M0. Materials and Methods: A total of 21 patients with a mean age of 71.5 years and a pathological diagnosis of renal cell carcinoma were treated with percutaneous computerized tomography guided cryoablation under conscious sedation on an outpatient basis. We retrospectively reviewed clinical data, tumor characteristics, techniques and results. Tumors with complete loss of contrast enhancement were considered successfully treated. Results: A total of 21 patients with 23 tumors underwent 25 cryoablation sessions. The mean intraoperative computerized tomography scan tumor size was 2.1 cm (range 0.5 to 4.3) and the mean ice ball size was 4.1 cm (range 2.2 to 7.2). Of the patients 82.6% (19 of 23) had a single treatment. Patients were followed with postoperative scans of 4.6 to 18.3 months (mean 12.3). There were 2 recurrences. The rate of successful complete tumor ablation was influenced by various factors. Tumor location and size were the major determinants for achieving tumor eradication. Conclusions: Percutaneous renal cryoablation using computerized tomography imaging proved to be a successful technique for guiding probe placement and monitoring ice ball formation. Patient selection based on tumor size and location may aid in improved outcomes. Further study and followup are necessary to determine long-term oncological efficacy. © 2006 American Urological Association. |
| Keywords: | treatment outcome; aged; aged, 80 and over; middle aged; surgical technique; histopathology; cancer localization; cancer recurrence; cancer patient; cancer staging; follow up; computer assisted tomography; tomography, x-ray computed; patient assessment; retrospective study; kidney carcinoma; kidney neoplasms; postoperative complication; carcinoma, renal cell; evaluation; contrast enhancement; cancer size; outpatient department; therapy effect; cryosurgery; dental anesthesia |
| Journal Title: | Journal of Urology |
| Volume: | 176 |
| Issue: | 5 |
| ISSN: | 0022-5347 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2006-11-01 |
| Start Page: | 1963 |
| End Page: | 1968 |
| Language: | English |
| DOI: | 10.1016/j.juro.2006.07.040 |
| PUBMED: | 17070219 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 25" - "Export Date: 4 June 2012" - "CODEN: JOURA" - "Source: Scopus" |
