Principles and use of anti-CTLA4 antibody in human cancer immunotherapy Journal Article
| Authors: | Peggs, K. S.; Quezada, S. A.; Korman, A. J.; Allison, J. P. |
| Article Title: | Principles and use of anti-CTLA4 antibody in human cancer immunotherapy |
| Abstract: | Cytotoxic T lymphocyte antigen-4 has become recognized as one of the key negative regulators of adaptive immune responses, having a central role in the maintenance of peripheral tolerance and in shaping the repertoire of emergent T cell responses. Concurrent recognition of the potential importance of inhibitory immune regulators in limiting antitumor responses, either as a result of chronic antigenic stimulation or the self-nature of many tumor-selective target antigens, has led to the development of cytotoxic T lymphocyte antigen-4-blocking antibodies as therapeutic anticancer agents. Following extensive preclinical modeling, these agents have entered clinical trials, where they are showing encouraging activity in heavily pretreated patients with advanced-stage disease, particularly with melanoma or renal carcinoma. Finding ways to dissociate antitumor activity from adverse immune events should enable actualization of their therapeutic potential in the coming years. © 2005 Elsevier Ltd. All rights reserved. |
| Keywords: | clinical trial; review; hepatitis; nonhuman; cancer staging; neoplasms; t lymphocyte; animals; interleukin 2; cancer immunotherapy; melanoma; ovary cancer; gastrointestinal symptom; kidney carcinoma; immunoregulation; rash; antibodies, monoclonal; immune response; immunotherapy; antigens, neoplasm; cell migration; tumor immunity; colitis; antigens, cd; colon carcinoma; cytotoxic t lymphocyte antigen 4; antibodies, neoplasm; antigens, differentiation; uveitis; antigen-antibody reactions; hypophysitis; models, immunological; antigen function |
| Journal Title: | Current Opinion in Immunology |
| Volume: | 18 |
| Issue: | 2 |
| ISSN: | 0952-7915 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-04-01 |
| Start Page: | 206 |
| End Page: | 213 |
| Language: | English |
| DOI: | 10.1016/j.coi.2006.01.011 |
| PUBMED: | 16464564 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 158" - "Export Date: 4 June 2012" - "CODEN: COPIE" - "Source: Scopus" |
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