Chemotherapy and the treatment of brain metastases Journal Article
| Authors: | Peak, S.; Abrey, L. E. |
| Article Title: | Chemotherapy and the treatment of brain metastases |
| Abstract: | Chemotherapeutic options for patients with brain metastases are limited. While surgery and RT are the most effective therapies for patients with brain metastases, there have been some encouraging developments with chemotherapy. Perhaps a better understanding of the molecular biology leading to brain metastases will yield more promising therapies. Identifying ways of bypassing the BBB to deliver effective therapies, but avoiding clinically significant toxicities, is an important area for exploration. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | cancer chemotherapy; cancer survival; cancer surgery; thalidomide; clinical trial; review; cancer recurrence; drug efficacy; monotherapy; multimodality cancer therapy; antineoplastic agents; pathophysiology; capecitabine; cancer radiotherapy; combined modality therapy; methotrexate; temozolomide; brain radiation; brain neoplasms; melanoma; biology; bone marrow suppression; lung non small cell cancer; oxygen; antineoplastic activity; drug effect; central nervous system; monoclonal antibody; aminotransferase blood level; glioblastoma; radiosurgery; blood brain barrier; blood-brain barrier; gefitinib; brain metastasis; aminotransferase; breast adenocarcinoma; abnormally high substrate concentration in blood; drug treatment failure; hand foot syndrome; absence of side effects; hypoxemia; radiosensitizing agent; multiple cancer; gadolinium texaphyrin; radiosensitization; efaproxiral; glycoprotein p; systemic disease; brain tissue; valspodar |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 20 |
| Issue: | 6 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-12-01 |
| Start Page: | 1287 |
| End Page: | 1295 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2006.09.007 |
| PUBMED: | 17113463 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 4 June 2012" - "CODEN: HCNAE" - "Source: Scopus" |
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