Targeted therapy for metastatic renal cell carcinoma Journal Article
| Authors: | Patel, P. H.; Chaganti, R. S. K.; Motzer, R. J. |
| Article Title: | Targeted therapy for metastatic renal cell carcinoma |
| Abstract: | Metastatic renal cell carcinoma (RCC) has historically been refractory to cytotoxic and hormonal agents; only interleukin 2 and interferon alpha provide response in a minority of patients. We reviewed RCC biology and explored the ways in which this understanding led to development of novel, effective targeted therapies. Small molecule tyrosine kinase inhibitors, monoclonal antibodies and novel agents are all being studied, and phase II studies show promising activity of sunitinib, sorafenib and bevacizumab. The results of phase III studies will determine the role of these agents in metastatic RCC. © 2006 Cancer Research. |
| Keywords: | gene mutation; clinical trial; fatigue; sorafenib; bevacizumab; cytotoxic agent; erlotinib; sunitinib; cancer combination chemotherapy; diarrhea; drug efficacy; hypertension; side effect; benzenesulfonates; pyridines; hand foot skin reaction; alpha interferon; gene; interleukin 2; metastasis; anemia; leukopenia; mucosa inflammation; nausea; stomatitis; thrombocytopenia; gene function; drug effect; histology; kidney carcinoma; kidney neoplasms; monoclonal antibody; protein tyrosine kinase inhibitor; temsirolimus; aspartate aminotransferase blood level; asthenia; cancer hormone therapy; rash; aspartate aminotransferase; antibodies, monoclonal; carcinoma, renal cell; enzyme inhibitors; drug response; acne; neoplasm metastasis; erythema; outcomes research; short survey; protein-tyrosine kinases; von hippel-lindau; vhl gene; indoles; pyrroles; abnormally high substrate concentration in blood; x ray crystallography; hand foot syndrome; alopecia; proteinuria; hyperlipidemia; clinical trials; palm erythema; cci-779; acne like rash; foot erythema |
| Journal Title: | British Journal of Cancer |
| Volume: | 94 |
| Issue: | 5 |
| ISSN: | 0007-0920 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2006-03-13 |
| Start Page: | 614 |
| End Page: | 619 |
| Language: | English |
| DOI: | 10.1038/sj.bjc.6602978 |
| PUBMED: | 16465192 |
| PROVIDER: | scopus |
| PMCID: | PMC2361211 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 102" - "Export Date: 4 June 2012" - "CODEN: BJCAA" - "Source: Scopus" |
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