Targeting von Hippel-Lindau pathway in renal cell carcinoma Journal Article

  


Authors: Patel, P. H.; Chadalavada, R. S. V.; Chaganti, R. S. K.; Motzer, R. J.
Article Title: Targeting von Hippel-Lindau pathway in renal cell carcinoma
Abstract: Inheritance of a defective copy of the von Nippel-Lindau (VHL) gene leads to the most common cause of inherited renal cell carcinoma (RCC). In addition, most patients with sporadic RCC have aberrant VHL. In the absence of VHL, hypoxia-inducible factor α accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. We review here the biology of RCC and how a combination of proximal and distal block of VHL/hypoxia-inducible factor α pathway by novel targeted agents, including sunitinib, sorafenib, bevacizumab, everolimus, and temsirolimus, has led to significant improvements in progression-free survival. © 2006 American Association for Cancer Reseach.
Keywords: signal transduction; platelet derived growth factor; vasculotropin; cancer survival; treatment response; clinical trial; pathogenesis; sorafenib; bevacizumab; placebo; sunitinib; cancer growth; monotherapy; benzenesulfonates; pyridines; alpha interferon; biomedical research; models, biological; angiogenesis; kidney carcinoma; kidney neoplasms; temsirolimus; carcinoma, renal cell; enzyme inhibitors; tumor cell; indoles; pyrroles; dna binding; growth factor; hypoxia inducible factor 1alpha; everolimus; sirolimus; von hippel lindau protein; von hippel-lindau tumor suppressor protein
Journal Title: Clinical Cancer Research
Volume: 12
Issue: 24
ISSN: 1078-0432
Publisher: American Association for Cancer Research  
Date Published: 2006-12-15
Start Page: 7215
End Page: 7220
Language: English
DOI: 10.1158/1078-0432.ccr-06-2254
PUBMED: 17189392
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33846203776&partnerID=40&md5=f216666a226337dec027e4e648687d27
Notes: --- - "Cited By (since 1996): 72" - "Export Date: 4 June 2012" - "CODEN: CCREF" - "Source: Scopus"
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MSK Authors
  1. Robert Motzer
    1243 Motzer
  2. Premal Patel
    9 Patel
  3. Rajendrakumar Sai Venkata Chadalavada
    10 Chadalavada
  4. Raju S K Chaganti
    391 Chaganti
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